Matchmaking for proposals for the 6th Call

Background Information

In 2023, the Shakahola region in Kilifi County, Kenya, experienced a tragic event involving the discovery of mass graves tied to a religious cult in the nearby Shakahola Forest. The cult allegedly convinced followers, including children, to engage in many days of uninterrupted fasting with promises of salvation, resulting in devastating loss of lives and suffering among the followers. The aftermath of this event left the region in a state of crisis, with significant mental health concerns among the local community, and especially children who witnessed or were indirectly affected by the tragic event in their region.

Post-crisis mental health assessments are crucial in understanding the short- and long-term effects of traumatic events on children. The well-being of school-going children in Shakahola is directly tied to their ability to cope, learn, and develop into healthy adults. However, little is known about the mental health impact of this specific crisis on the children in the region. This study seeks to address this knowledge gap by conducting a post-crisis mental health assessment of school-going children, intending to inform interventions to support their recovery.

Problem Statement

In the aftermath of the crisis in Shakahola, there is an urgent need to assess the mental health of affected children. These children might be experiencing increased emotional distress, yet they live in a community with limited mental health resources. Without prompt intervention, their mental health issues could affect their academic performance, social relationships, and long-term development. The absence of current data on their mental health after the crisis makes it hard to create targeted support programs. This study aims to evaluate the mental health effects of the crisis on school children in Shakahola, identify key contributing factors, and suggest appropriate interventions to promote resilience and recovery.

Study Objectives

• 1. To assess the prevalence and severity of mental health issues such as anxiety, depression, post-traumatic stress disorder (PTSD), and behavioral disorders among school-going children in Shakahola following the continuous crisis.

• 2. To identify socio-economic, familial, and environmental factors that have influenced the mental health of children in the region post-crisis.

• 3. To evaluate the availability, accessibility, and effectiveness of mental health support systems for children in Shakahola.

• 4. To develop recommendations for post-crisis mental health interventions in schools and communities

• 5. To work on the socio-economic support recommended to support the children who suffer loss of parents, post-traumatic stress disorders, and school dropout.

Methodology

This study will adopt a mixed-methods approach to comprehensively assess the mental health status of school-going children in the Shakahola region following the recent crisis. The methodology combines quantitative and qualitative techniques to provide both statistical analysis and in-depth insights into the children's mental health conditions.

Study Design

The study will be a cross-sectional, descriptive survey with elements of comparative analysis (with mental health assessments done in schools from other regions in Kilifi) to evaluate the current mental health status of children and examine the impact of the recent crisis. The use of both quantitative and qualitative methods will allow for a deeper understanding of the factors affecting mental health in this population.

Study Population

The study will focus on school-going children aged 6–18 years in the Shakahola region. These children represent a vulnerable group that has experienced the recent crisis and are now coping with its aftermath. Both primary and secondary schools in the region will be included in the study.

Sampling Strategy

The study will involve 400 students from a primary school and 200 students from a secondary school in Shakahola region. These two schools are strategically situated and purposely chosen due to their vicinity to the event site.

Contact: Alice Anika –Pwani University, School of Education, Educational Psychology and Special Needs Department, a.anika@pu.ac.ke

Abstract

Agriculture remains the backbone of livelihoods in Sub-Saharan Africa, yet it is increasingly threatened by climate variability, land degradation, and unsustainable farming practices. Building resilient and sustainable farming systems is therefore critical to achieving food security, poverty reduction, and environmental sustainability in the region. This project, “Building Climate-Resilient and Sustainable Farming Systems in Sub-Saharan Africa through Austria–Africa Partnerships”, seeks to foster joint research, knowledge exchange, and innovation between Austrian and African partner institutions. The initiative will combine Austria’s expertise in sustainable agricultural technologies, agroecological practices, and climate-smart innovations with African partners’ deep knowledge of local farming systems, indigenous practices, and community-based adaptation strategies. Through a multi-stakeholder approach, the project will focus on three core areas: developing and testing climate-resilient and sustainable agricultural practices; strengthening farmers' capacities through participatory training, co-creation, and knowledge transfer; and enhancing policy dialogue and institutional collaboration to scale best practices across Sub-Saharan Africa. By linking research with practice, the project aims to generate context-specific solutions that enhance soil health, improve water management, and promote crop diversification, while reducing vulnerability to climate-related shocks. In doing so, it will contribute to Africa-UniNet’s objectives of fostering equitable Austria–Africa partnerships, advancing scientific cooperation, and supporting the UN Sustainable Development Goals (SDGs), particularly SDG 2 (Zero Hunger) and SDG 13 (Climate Action).

Contact: Faraja Sanga (PhD), Ruaha Catholic University, Department of Humanities, Iringa, Tanzania, faraja.sanga@rucu.ac.tz
 

Abstract

Access to affordable, reliable, and clean energy remains a critical challenge in Sub-Saharan Africa, where millions of people still depend on traditional biomass and fossil fuels for daily needs. This dependence exacerbates poverty, increases health risks, and contributes to environmental degradation, while limiting opportunities for inclusive development. At the same time, the region faces urgent climate vulnerabilities that demand a rapid yet just transition to sustainable energy systems. The project, “Accelerating the Transition to Clean Energy for Creating a Just and Equitable Climate Future in Sub-Saharan Africa”, aims to foster Austria–Africa partnerships to drive innovation, capacity building, and policy support for clean energy transitions that leave no community behind. The initiative will integrate Austrian expertise in renewable energy technologies, energy efficiency, and climate policy with African partners’ contextual knowledge, community networks, and indigenous energy practices. Activities will focus on three priority areas: developing and piloting decentralized renewable energy solutions for rural and peri-urban communities; enhancing knowledge exchange and technical training to build local capacity for clean energy deployment; and supporting inclusive policy frameworks that promote energy justice, gender equity, and community participation in energy planning. By advancing equitable access to clean energy, the project aims to reduce greenhouse gas emissions, enhance livelihoods, and enhance climate resilience in Sub-Saharan Africa. In doing so, it will directly contribute to Africa-UniNet’s goals of fostering collaborative research between Austria and Africa, while supporting the UN Sustainable Development Goals, particularly SDG 7 (Affordable and Clean Energy), SDG 10 (Reduced Inequalities), and SDG 13 (Climate Action).

Contact: Faraja Sanga (PhD), Ruaha Catholic University, Department of Humanities, Iringa, Tanzania, faraja.sanga@rucu.ac.tz

Abstract

Accurate and reliable diagnosis is critical for the effective management of malaria in pregnancy (MiP), yet it remains a major challenge. According to WHO guidelines, malaria diagnosis should be confirmed using either microscopy or rapid diagnostic tests (RDTs) before treatment (Makuuchi et al., 2017) . However, these conventional tools often fail to detect low-density parasitaemia, mixed-species infections, and non-falciparum malaria, leaving many cases undiagnosed (Budodo et al., 2025; Tamir et al., 2025). These hidden infections, many of which are asymptomatic, act as silent reservoirs that sustain transmission and contribute to adverse maternal and neonatal outcomes such as maternal anaemia, low birth weight, and increased morbidity and mortality (Alemayehu et al., 2024; Beeson & Opi, 2025). 
Advanced molecular tools such as multiplex qPCR provide superior sensitivity and enable differentiation of Plasmodium species, thereby overcoming the limitations of microscopy and RDTs (Dahal et al., 2021; Opoku Afriyie et al., 2023). This study seeks to address the diagnostic gap in Busia County, a high-transmission setting, by detecting malaria parasites in pregnant women at delivery using microscopy, mRDT, and qPCR; estimating the prevalence of MiP, and identifying Plasmodium species. Findings from this study will establish accurate diagnostic tools for MiP, reveal the hidden burden of submicroscopic and non-falciparum malaria, and provide evidence to guide National Malaria Control Programme policies. Ultimately, the study will inform decisions on diagnostic strategies, support timely treatment, and contribute to the reduction of maternal and fetal morbidity and mortality, advancing progress toward malaria elimination.

Contact: Bartholomew Ondigo, Egerton University, Kenya, ondigo2002@gmail.com

Abstract

The Southern Highlands of Tanzania are critical for national food production, hydropower generation, and water supply for downstream communities. However, the region is facing intensifying water insecurity due to seasonal variability, declining springs and shallow wells, and the degradation of catchments. The key drivers for water insecurity include massive expansion of pine and eucalyptus plantations, which reduce water availability by increasing evapotranspiration and lowering groundwater recharge. The over drivers are agricultural encroachment into fragile catchment areas and poor land-use practices, including unsustainable farming on steep slopes. These pressures have contributed to declining base flows, seasonal drying of streams, contamination of water sources, and increased drought risks. Communities especially women and girls who shoulder the burden of water collection are disproportionately affected. Water insecurity undermines health (SDG 3), food security (SDG 2), gender equality (SDG 5), and livelihoods (SDG 1 and SDG 8). There is urgent need for integrated, climate-smart water management approaches that combine nature-based solutions, community-based governance, and resilient infrastructure to restore water security and safeguard ecosystem services. Goal of the project: To increase water security and climate resilience for vulnerable communities in the Southern Highlands of Tanzania through integrated catchment restoration and climate-smart water management. Specific Objectives of the project:  Restore and protect 3,000–5,000 hectares of degraded upland catchments through reforestation with indigenous species, controlled farming practices, and soil conservation measures, thereby improving base flows and reducing erosion, Rehabilitate and climate-proof small water supply and irrigation systems to ensure reliable, safe, and equitable water access for households and productive use in agriculture, Strengthen local governance and institutional capacity at community and district levels for sustainable and participatory water resource management and promote alternative livelihoods and climate-smart agriculture to reduce pressure on catchments while improving food security and incomes. The project will adopt a participatory, multi-stakeholder approach that integrates scientific knowledge, traditional practices, and local governance structures. Collaboration with Africa-UniNet will enable technical exchange, capacity building, and applied research on water-forest-agriculture interactions.

Contact: Faraja Sanga (PhD),  Ruaha Catholic University, Department of Humanities, Iringa, Tanzania, faraja.sanga@rucu.ac.tz 

Abstract

Cashew Nut Shell Liquid (CNSL) is a renewable and non-edible by-product of the cashew processing industry. While it has been transformed to many useful products in developed countries, it is majorly a waste product in many African countries where cashew trees are majorly found. CNSL is a promising raw material for different chemistry synthesis and applications due to its unique phenolic composition, biodegradability, and availability. Its three major isolates (anacardic acid, cardol and cardanol) have been transformed into many useful products. Some metal complexes with very good antibacterial properties of these isolates have been established. This research proposes the development of sustainable metal complexes of saturated cardol and cardanol, with possible antimicrobial, anticancer, antihypertensive, and antidiabetic applications.

The study aims to utilize both cardol and cardanol to synthesize these complexes via direct mixing and co-precipitation methods. The research will be a collaborative effort between chemists, biologists and pharmacologists. Some cardanol/cardol-complexes with very good therapeutic applications are expected from this research, which can be further processed for drug discovery and development. It is expected that the success of the research will not only minimize waste but transform waste to wealth, thus achieving double benefits.

Contact: Oke David Gbenga, Bowen University, oke.david@bowen.edu.ng

Abstract

Aquaculture presents a transformative opportunity for rural livelihoods in Kenya by enhancing food security, increasing income, and reducing poverty. However, its expansion is hindered by the reliance on fishmeal—an expensive and ecologically unsustainable protein source for aqua feeds. Concurrently, malnutrition remains a critical challenge, necessitating innovative, nutrition-sensitive interventions. The NutriSaq project proposes integrating Spirulina (Arthrospira fusiformis) farming into small-scale aquaculture systems as a sustainable solution to enhance feed availability, improve nutrition, and create economic opportunities. Spirulina, a nutrient-rich microalga, offers a high-protein, essential amino acid, and micronutrient profile while promoting circular economy principles through resource-efficient production and reduced environmental impacts. This project pursues three key objectives: (i) integrating Spirulina farming within smallholder aquaculture to enhance cost-effective, high-quality fish feed production; (ii) improving household nutrition by evaluating the dietary impact of Spirulina-enriched aquaculture products in mitigating malnutrition; and (iii) assessing economic benefits, and gender-inclusive livelihood opportunities associated with integrated aqua-spirulina farming. A mixed-methods approach will be employed, including participatory training, demonstration plots at Maseno University, and technical support to facilitate adoption. Adoption rates and system performance will be monitored through surveys and field observations. Nutritional benefits will be assessed via laboratory analysis of Spirulina-enriched fish for protein, omega-3, and micronutrient content.  Economic and social impacts will be evaluated using cost-benefit analysis, econometric modeling, and qualitative assessments. Environmental sustainability will be monitored through water quality testing and life cycle assessments. NutriSaq will foster resilient livelihoods and enhance food and nutrition security for rural Kenyan communities by addressing key constraints in feed costs and malnutrition.

Contact: Oscar Ouma, Maseno University, Kenya, kaudo2015@gmail.com

Abstract

The Lake Victoria Basin (LVB) is an important regional socio-ecological system that supports multiple economic activities including tourism. However, the ecosystem faces a myriad of threats to their functions; climate change being the most prominent. Climate change has negatively affected sustainability of the tourism sector in the LVB since the industry is highly dependent on natural resources. Thus necessitates the tourism sector in the LVB to adapt to a changing climate. This project will adopt ecosystem-based adaptation approaches to climate change impacts on tourism in LVB, Kenya; which is currently limited. The project  will investigate the application of ecosystem-based adaptation approaches to overcome impacts of climate change on the tourism sector in LVB, Kenya. The partnership aims at mutual transfer of knowledge, research expertise and skills that will aid in addressing development gaps of the partnered countries. The study will address the following research questions: (i) what are the perceived impacts of climate change on tourism in the LVB, East Africa ? (ii) Which ecosystem-based adaptation approaches to climate change have been implemented by the tourism sector in the LVB, East Africa? (iii) What trade-offs and synergies result from the implementation of ecosystem-based adaptation strategies in LVB, East Africa? (iv). How does the trade-offs and synergies contribute to the long term sustainability of tourism in the LVB, East Africa ? The study findings will be used to train professionals in tourism on ecosystem-based adaptation approaches to climate change and inform policy makers and host communities on ecosystem-based adaptation approaches that will enhance sustainability of the tourism sector in East Africa.

Contact: Oscar Ouma, Maseno University, Kenya, kaudo2015@gmail.com

Abstract

Climate change-induced extremes like droughts and floods disproportionately impact women and men in Kenya’s agro-pastoral communities due to pre-existing gender inequalities. Standard Early Warning Systems (EWS) often overlook these gendered dimensions, leading to ineffective warnings, response and mal-adaptation. The G-REWAS project will addresses this critical gap. The project will use participatory action research to design gender-responsive EWS and adaptation strategies. The project will further intergrate local gendered knowledge with scientific data to enhance community resilience, directly contribute to SDGs 5 (Gender Equality), 13 (Climate Action), and 2 (Zero Hunger) to establish a sustainable framework for gender inclusive climate risk management.

Contact: Prof. Nelson Obange (PhD), Maseno University, Kenya, nelson.obange@gmail.com; nobange@maseno.ac.ke

Abstract

The population of countries in Africa is growing at an alarming rate engendering massive turnout of wastes in liquid and solid forms. This in turn have resulted in the ugly waste accumulation and environmental degradation scenario currently experienced in most African countries to which a sustainable solution is yet to be provided. To address this trend in waste generation and improper management, it is imperative to develop sustainable solutions via the deployment of microbial-based biorefineries in order to achieve a circular bioeconomy for the continent. Biorefineries offers efficient and environmentally-friendly solutions geared towards the generation of multiple products from a single waste stream. In this regard, this grant will be deployed in the creation of awareness of biorefineries and circular bioeconomy across Africa as a pioneering initiative. The target audience will be undergraduate students in selected Universities in Nigeria, South Africa, Egypt and Rwanda. These students will be formed into special campaign groups and will be coordinated by partnering lecturers and mentors from across the Universities. Awareness will take the form of town hall meetings, print and online media and inter-university visitations. It is hoped that these students who will imbibe the culture of sustainable management will become ambassadors to further spread the knowledge and create enabling influences on the society in form of trainings after graduation. It is hoped that the project will help create a new wave of research, awareness, knowledge transfer and sustainable industry partnerships on the need to establish biorefineries in Africa towards the creation of a circular bioeconomy for the continent. The horizon of the project will widen with more funding from others sources afterwards.

Contact: Olatunde Samuel Dahunsi, Bowen University, Nigeria, olatunde.dahunsi@bowen.edu.ng 

Abstract

Soil nutrient depletion is a recurrent scenario across African countries and has caused enormous nutrient loss and have contributed immensely to food insecurity and climate adaptation. Chief among the nutrients is Nitrogen, a macroelement and an essential component of amino acids is one of the major constituents of the atmosphere, comprising 78% of the total atmospheric gas. However, this important element cannot be fixed directly by both plants and animals but could be obtained from other organic sources. Nature has devised a means to balancing this deficit in nitrogen utilization by equipping microbes with the capacity to fix atmospheric nitrogen directly to plants either as free-living fixers or as symbiotic fixers. Biological nitrogen fixation is an environment-friendly process that is reported to the ammonium form of nitrogen which can be converted to other forms of nitrogen. The roots of vegetables like legume (cowpea) are noted for developing symbiotic relationship with nitrogen fixing rhizobia thus making atmospheric nitrogen available for legume utilization. Similarly, Azospirillum, an associative nitrogen fixer is extensively reported to be able to fix nitrogen directly to the roots of grasses and cereals through symbiotic association with them. Whereas, Azotobacter are free living nitrogen fixer capable of nitrogen fixation in grasses such as rice, millet, maize etc. It is therefore proposed in this research to explore the possible synergistic effects of combining the nitrogen fixing bacteria as biofertilizers by inoculating them onto a nitrogen-free or poor organic soil structure amender i.e., biochar in order to enhance the modification of soil structure, increase ionic reactions as well supplying ample amount of nitrogen to the soil and the crops planted on it i.e., vegetables and legume. The technological gap to be filled in validating this innovation will be a robust and accurate field measurements of biological nitrogen fixation by deploying novel biosensors, spectral analysis, infra-red and or any other fast and low-cost methodology. This will help to develop strategies to reduce greenhouse gases (GHG) emissions, fertilizer runoff, and water pollution. Besides, the grant will be use to create awareness and promotion of the newly developed biofertilizer and this will further boost its adoption and application on the industrial scale.

Contact: Olatunde Samuel Dahunsi, Bowen University, Nigeria, olatunde.dahunsi@bowen.edu.ng

Abstract

Green marketing practices is an approach that encompasses various actions and practices such as altering products, changing production processes, adjusting to environmentally sustainable packaging, introducing sustainable distribution channels, and modifying communication, all aimed at reducing negative environmental impact and enhancing sustainability in business dealings (Khandelwal & Yadav, 2014). Majority of the studies (Fraj et al, 2011; Ko & Jeon, 2024; Utama, 2024; Al-Dmour et al, 2023; Choudhury et at, 2019; Zampese et al, 2016; Khaleeli et al, 2021; Mukonza and Swarts, 2020) and Afande, 2015) reviewed on Green marketing practices were from the non-food and beverage manufacturing sub-sector such as non-profit organization, construction industry, service sector, retail sector, etc. Consequently, little is known about the status and the effect of green marketing practices on the sustainable manufacturing of Kenya's food and beverage manufacturing sector.

1.1 Objectives
To examine how gender parity can leverage the sustainable manufacturing of Kenya’s food and beverage sector. To analyze how green marketing practices can leverage the sustainable manufacturing of Kenya’s food and beverage sector.

1.2 Research Questions
How does gender parity leverage the sustainable manufacturing of Kenya’s food and beverage sector? 
How does green marketing practices leverage the sustainable manufacturing of Kenya’s food and beverage sector?

1.3 Proposed Methodology
The study will be conducted in Kenya’s food and beverage sector comprising a KAM membership of about 181 clustered as follows: dairy and meat processing firms, grain milling firms, edible fats and oils processing firms, beverages, fruits, and vegetable processing firms, fish processing firms, wines, and beer and spirits firms. Top directors, managers, and employees of these firms will be targeted. The study will employ a mixed methodology research design, using the pragmatic approach. We will conduct a scoping study of the food and beverage manufacturing sector to appraise the state of the sector. We will identify a representative sample of key industry stakeholders for an inception meeting. Alongside this inception meeting, we will conduct key informant interviews concurrently. Thereafter we will design a quantitative study to collect data in line with the research questions. We will develop and validate an online questionnaire and implement it using Kobo Collect Toolbox. The quantitative data will be summarised, and analysed to test statistical significance using multiple regression models. The output of these results will be presented to a panel of stakeholders at a closing meeting to be validated. We expect stakeholder input in shaping the policy directions regarding outcomes of the project. These will be documented in reports for external policy dialogues.

Contact: Prof. Fredrick Aila, Maseno University, Kenya, faila@maseno.ac.ke

Abstract

Textile-based dye-sensitized solar cells (TDSSCs) are potential energy sources for wearable electronics due to the advantageous characteristics of textile materials. Dyes serve as crucial photosensitizers in the efficiency and functionality of these flexible solar cells. Typically, TDSSCs utilize synthetic dyes that are non-biodegradable and often contain hazardous heavy metals. Nonetheless, substituting synthetic dyes with inexpensive, biodegradable natural dyes can yield TDSSCs that are both cost-effective and environmentally sustainable. Moreover, Nigeria possesses a rich diversity of native flora capable of yielding natural dyes with potentially favourable photochemical characteristics. Consequently, this research will explore various indigenous natural dyes to determine those that exhibit extensive absorption spectra for use as effective photosensitizers in TDSSCs.Metal oxide semiconductors such as TiO2 and ZnO serve as photoanodes in TDSSCs, but they face challenges including prolonged dye absorption times, dye complex formation, and significant charge recombination at the electrolyte interface. These issues may be mitigated by incorporating metal-organic frameworks (MOFs) into photoanodes, thereby enhancing properties such as porosity, surface area, electron transport, and intra-framework functionality.This research will integrate various MOF structures into ZnO photoanodes to improve dye loading capacity and minimize charge recombination losses. Additionally, the implementation of polymer-based gel and MOF-based electrolytes will be demonstrated to enhance the long-term stability of TDSSCs. This project aims to significantly advance the development of low-cost, ecofriendly textile-based DSSCs as sustainable energy sources for Wearable electronic applications in sports and health. Additionally, the project seeks to foster collaborative research between Austrian and African scholars while contributing to the United Nations Sustainable Development Goals #7 (Affordable and clean energy), #13 (Climate action), #3 (Good health and well-being), and #4 (Quality education).

Contact: Dr. Ayodele Soge, Redeemer’s University, Department of Physical Sciences, Faculty of Natural Sciences, Ede, Osun State, Nigeria, sogea@run.edu.ng

Abstract

Simulated DHR curriculum is essential to provide learners with a safe hands-on environment in which to apply evidence-based guidelines while learning DHR skills, but there aren't a DHR curriculum in faculty of nursing, Damanhour University that teach students how to use them optimally. So, in this project a Sim -DHR curriculum will be established using a DHR training platform identical to the hospital’s DHR system. The academic staff members and internship nursing students, as part of their required work in hospitals, will be trained to complete the simulated DHR curriculum. Learners will use, check and correct a simulated medical chart for a complex virtual patient. 

Objectives:
This project aims to
1. Construct Simulated DHR curriculum in nursing education
2. Train nursing students and academic staff how to use simulated DHR

Methods:
60 academic nursing staff educators and 440 internship nursing students will be involved in an educational program. They will be divided into 25 groups. The educational program will include 3 sessions for 3 consecutive days; each session will take a duration of 5 hours. They will be trained to use simulated DHR in computer and simulation (OSCE) labs. Sim-digital health records software system will be composed of patient personal history, patient admission and discharge, patient personal history, patient physical examination, patient system review, patient numerical pain rating, physician physical restraint order and nurse follow up, patient consultation request, discharge summary, vital signs observational record, fluid balance observational record, medication administration record, patient requested lab investigation record, patient intra operative anesthetic record. Skills demonstration and simulation evaluation, feedback surveys from participants, and continuous monitoring of progress are strategies will be used to evaluate performance of participants.

Contact: Intessar Abdelrahman, Critical care and emergency nursing department, faculty of nursing, Damanhour University, abdelrahman.intessar@gmail.com

Abstract

Soil fertility decline is a barrier to agricultural productivity in Africa, where smallholder farming constitutes a significant part of livelihoods. Among essential nutrients, phosphorus (P) deficiency is severe due to the dominance of highly weathered and acidic soils that strongly fix applied P fertilizers. Conventional synthetic inputs are costly, inefficient, and mostly imported. In Ethiopia, large amounts of agro-industrial waste are generated and often discarded, contributing to pollution and the underutilization of valuable resources. This project proposes the development of waste-derived nanofertilizers and coatings for slow-release phosphorus fertilizers for Ethiopian smallholder farmers. This represents technological innovations for improving sustainable farming in Ethiopia through learning from Austria's experience.

Ethiopia-Austria Africa-Uninet consortium will perform laboratory studies on material characterization and nutrient release kinetics combined with field trials on key Ethiopian crops. Agronomic performance will be assessed alongside environmental safety, including potential heavy-metal co-release and soil-microbiome interactions. Participatory engagement with smallholder farmers will guide adoption strategies, ensuring the formulations are both technically effective and socio-economically feasible. By converting waste into valuable fertilizers, this project promotes a circular economy, reduces reliance on costly imports, and enhances local innovation capacity. The results will directly support Ethiopia’s national goals for food security and sustainable agriculture while aligning with the UN Sustainable Development Goals.

Contact: Dr Menbere Mekonnen, Addis Ababa Science and Technology University, menbere.leul@aastu.edu.et

Abstract

Global food production is increasing, yet over one-third is lost postharvest, threatening food security and fuelling climate change. Low-income, food-deficit countries contribute 22% to global food loss, disproportionately affecting vulnerable groups, particularly women engaged in perishable produce trade. Inadequate cold chains are a major driver, causing losses of 526 million tons annually and reducing smallholder incomes by 15%. Uganda lags in cold storage capacity; for instance, in 2024, the bulk refrigerated storage capacity was only 4.5 m3/1,000 inhabitants, despite evidence that refrigeration could save 144 million tons globally. This study aims to (1) assess the magnitude, causes, and costs of postharvest losses in perishable value chains in urban Uganda, (2) co-create and test low-input off-grid preservation technologies using local resources, and (3) train and equip vendors to adopt these innovations. Findings will guide policies and investments for food security, resilience, and SDG 12 achievement.

Contact: Dr. Matia Mukama, Department of Food Science & Technology, Faculty of Science, Kyambogo University, Uganda. Email: mmatia@kyu.ac.ug

Abstract

High-Entropy Alloys (HEAs) epitomize a transformative class of materials that are characterized by their multi-principal element compositions. They offer exceptional mechanical, thermal, and chemical properties. This project focuses on the synthesis and comprehensive characterization of a novel HEA system comprising different elements. The strategic combination of these seven elements is expected to yield alloys with superior strength-to-weight ratios, enhanced corrosion resistance, and remarkable thermal stability properties, which are highly desirable for aerospace, energy, and biomedical applications. The research will employ advanced synthesis techniques such as mechanical alloying, spark plasma sintering, and powder metallurgy, followed by rigorous characterization using X-ray diffraction (XRD), scanning electron microscopy (SEM), energy-dispersive spectroscopy (EDS), and nanoindentation. Corrosion behaviour of the HEAs samples in two different corrosive media will be investigated using a potentiodynamic polarization device to obtain the open circuit potential (OCP), potentiodynamic polarization (PDP), and electrochemical impedance spectroscopy (EIS) data. The tribological behaviour of the developed HEAs will be examined using the Pin-on-Disc apparatus. The project also aims to investigate the microstructural evolution and mechanical behavior under extreme conditions to assess the alloy’s performance and reliability. This project is in proper alignment with several United Nations Sustainable Development Goals (SDGs); by fostering advanced materials development for next-generation technologies (SDG 9), through efficient use of elemental resources and sustainable manufacturing practices (SDG 12), and by enabling materials that improve energy efficiency and reduce emissions in industrial applications (SDG 13). Through the advancement of the frontier of HEA research, this project contributes to the global pursuit of sustainable, high-performance materials that support resilient infrastructure and environmentally conscious innovation.

Contact: Dr. Peter P. Ikubanni, Bowen University, Iwo, Osun State, Nigeria, peter.ikubanni@bowen.edu.ng

Abstract

Contamination of staple crops like maize, coffee, and sesame with carcinogenic aflatoxins is a major barrier to food security and economic development in Ethiopia. This project will develop a sustainable, enzyme-based detoxification solution by employing biocatalysts from indigenous microorganisms. Our approach integrates enzyme discovery, protein engineering, and process optimization to achieve efficient aflatoxin degradation under real-world post-harvest conditions. We will employ advanced analytical chemistry (HPLC/MS) to monitor efficiency and characterize non-toxic by-products, validated through rigorous toxicological assessments. The ultimate goal is a scalable, market-ready technology tailored to Ethiopia and adaptable across Africa.

Keywords: Aflatoxin; Food Safety; Enzyme Engineering; Biocatalysis; Post-Harvest Technology; Public Health; Ethiopia

Expertise sought from Austrian partners

We seek partners to form a consortium with complementary expertise in:

• Enzyme Engineering & Bioprocess Development: particularly in protein optimization, heterologous expression, formulation, and scale-up.
• Analytical Chemistry (HPLC/MS): For high-resolution quantification of aflatoxins and precise identification of degradation metabolites.
   

Our contribution
The Ethiopian team will lead critical components of this collaborative project, bringing essential expertise and resources. We will conduct the isolation and screening of indigenous microorganisms, perform preliminary enzymatic assays, and manage all field validation trials under real-world storage conditions in Ethiopia. Furthermore, we provide guidance on local agricultural practices, regulatory requirements, and stakeholder engagement, ensuring the developed technology is practical, adoptable, and sustainable within the Ethiopian context.

Expected impact and sustainability

• Public health: directly reduces exposure to aflatoxins, lowering the incidence of liver cancer and other related health burdens.
• Economic security: enhances the safety, quality, and marketability of key Ethiopian export commodities, boosting trade.
• Sustainability: the use of indigenous resources ensures the solution is affordable, accessible, and locally owned for the long term.
• SDG alignment: contributes directly to SDG 2 (Zero Hunger), SDG 3 (Good Health and Well-being), SDG 8 (Decent Work and Economic Growth), and SDG 17 (Partnerships for the Goals).
  
  Contact: Dr. Ebrahim Mama, ebrahim.mama@aastu.edu.et (Addis Ababa Science and Technology University)
   

Abstract
Ethiopia is renowned for its rich biodiversity, characterized by varied climatic zones and ecosystems that provide a suitable habitat for numerous mushroom species. Among these, edible and medicinal mushrooms hold the potential for nutritional enhancement and health benefits. Despite their significance, there is limited research on the diversity, nutritional value, and medicinal properties of these mushrooms in Ethiopia. This proposal aims to investigate the diversity, cultural significance, and potential health benefits of wild mushrooms in selected regions of Ethiopia. The study will employ field surveys, ethnobotanical research, laboratory analyses, and community engagement to gather quantitative and qualitative data. Expected outcomes include an enhanced understanding of local cultural practices, scientifically validated nutritional and medicinal information, promotion of food security, and stimulation of local economies through the responsible utilization of mushroom resources. Ultimately, this project aims to contribute to public health and nutritional enhancement while preserving the rich cultural heritage associated with mushroom use in Ethiopia. 

Objectives: 
This project aims to
1.    Identify edible and medicinal mushrooms across various ecological zones in Ethiopia.
2.    Provide scientifically validated information on the nutritional and medicinal properties of indigenous mushrooms.
3.    Document local knowledge regarding mushroom consumption and medicinal use among communities.
4.    Adopt and distribute seeds of selected mushroom species to the local community
 

Contact: Professor Zuriash Mamo  zuriash.mamo@aastu.edu.et (Assistant Professor in Industrial Biotechnology and early-career principal investigator at Addis Ababa Science and Technology University (AASTU); or Dr. Anegagregn Gashaw Ferede, Ph.D. ganegagregn@gmail.com

Abstract
Ethiopia is home to diverse medicinal plants that play a central role in traditional healthcare. Despite their potential, their wider use in nutraceuticals is limited by the poor bioavailability of active compounds and a lack of sustainable processing strategies. At the same time, the country’s rich microbial diversity from traditional fermented foods and medicinal plants remains largely untapped for biotechnological applications. This project proposes an innovative approach that combines these two resources to develop sustainable nutraceuticals.
The project will investigate the use of beneficial microbes from traditional foods and medicinal plants to ferment key medicinal plants, including Artemisia annua and Moringa oleifera. The enhancement of bioactivity will be rigorously assessed through in-vitro antioxidant and antimicrobial assays, alongside advanced chemical profiling using HPLC and GC-MS to understand metabolite changes. Participatory engagement with local experts and potential producers will guide the development of the protocol, ensuring the resulting nutraceutical precursors are both scientifically validated and socio-economically viable.  

By establishing a bio-enhancement protocol, the project aims to increase the therapeutic and commercial value of Ethiopian medicinal plants, promote local nutraceutical development, and reduce dependency on imported supplements. Austrian expertise in fermentation biotechnology and advanced analytics complements Ethiopia’s biodiversity and microbial resources, creating a mutually beneficial collaboration. The outcomes will support Ethiopia’s bioeconomy and directly contribute to the UN Sustainable Development Goals on health and innovation.

Contact: Dr. Ebrahim Mama, Addis Ababa Science and Technology University, Ethiopia, ebrahim.mama@aastu.edu.et

Abstract

The burden of cancer is rising globally, particularly among older adults in low- and middle-income countries such as Uganda. Older adults frequently experience multimorbidity, with coexisting chronic conditions such as hypertension, diabetes, and cardiovascular disease, which complicate cancer prevention, detection, and management. Evidence indicates that cancer risk in later life is influenced by cumulative exposures across the lifespan, including nutrition, lifestyle, infections, environmental factors, and social determinants. Understanding these influences is critical for designing interventions that promote healthy aging and enhance quality of life.

This study investigates how life-course exposures contribute to cancer risk and quality of life among adults aged 50 years and older in Uganda. Key exposures include dietary transitions, physical activity patterns, infections such as HPV or hepatitis, environmental carcinogens, and urban versus rural upbringing. The study employs a cross-sectional design with a retrospective component, using structured questionnaires and life-history calendars to capture childhood, adolescent, and adult exposures. Current cancer status and risk factors will be assessed through clinical evaluation, relevant biomarkers (e.g., HPV and hepatitis serology, blood pressure, glucose, lipid profiles), and self-reported medical history. Quality of life and multimorbidity will be evaluated using validated instruments, such as the WHOQOL-BREF and Charlson Comorbidity Index. Early-life exposures will be approximated through participant recall and community-level historical data, including nutrition transitions, endemic infections, and environmental exposures.

We welcome collaborations from researchers and institutions interested in cancer epidemiology, gerontology, and public health interventions. Opportunities include biomarker analysis, methodological innovations, multi-site data collection, and expansion to additional populations. By linking life-course exposures with cancer risk, multimorbidity, and quality of life outcomes, this research provides a platform for multidisciplinary partnerships aimed at improving cancer prevention and promoting healthy aging among older adults in Uganda and similar contexts.

Contact: Dr. Deusdedit Tusubira, PhD, Mbarara University of Science and Technology, Uganda, dtusubira@must.ac.ug

Abstract

This project aims to advance the development of novel hybrid chemical structures designed to simultaneously inhibit carbonic anhydrase (CA) and cyclooxygenase (COX-1/COX-2) enzymes, offering a promising multi-target strategy for the treatment of neuropathic pain and neuroinflammatory disorders. Preliminary biochemical studies have confirmed the compounds’ potent inhibitory activity and selectivity toward CA and COX isoforms.
The next phase of this project will focus on cellular validation, specifically assessing the compounds’ ability to modulate key inflammatory mediators such as TNF-α, IL-6, and iNOS, and evaluating their efficacy in neuroinflammatory cellular models (e.g., microglia and astrocytes). By combining synthetic chemistry expertise from Egypt with advanced cellular pharmacology capabilities in Austria, this project will generate critical translational insights and foster sustainable scientific exchange.

The outcomes are expected to identify lead candidates for preclinical development while strengthening Africa–Austria partnerships in drug discovery and neuroinflammation research.

Contact: Dr. Mahmoud A. Ragab, Damanhour University, Egypt, mahmoud.ragab@pharm.dmu.edu.eg 

Abstract

Agricultural extension is central to Botswana’s agricultural transformation agenda under Vision 2036 and the National Agricultural Investment Plan (2017–2023). Yet, extension delivery remains challenged by weak research–practice linkages, limited human resources, and insufficient use of ICTs and participatory approaches (Tladi-Sekgwama, 2019; Noga, 2018; Torimiro and Igodan., 2019, Torimiro, 2025). The Botswana University of Agriculture and Natural Resources (BUAN) has developed a University Extension Strategy Framework (Torimiro, 2025), anchored on the Agricultural Media Resources and Extension Laboratory (AMREL), On-Station/On-Farm Demonstration Sites, Adopted Village Extension Programme, and Innovation Platforms. However, operationalising this framework requires structured collaboration with the Ministry of Lands and Agriculture (MoLA).

This 18-month Africa-UniNet project will co-design and pilot a small-scale, ICT-enabled BUAN–MoLA extension linkage in Oliphant drifts, an adopted village of BUAN. The project will: (1) conduct institutional mapping and needs assessment, (2) co-develop AMREL digital extension prototypes (video, radio, Interactive Voice Response (IVR)/SMS), (3) establish participatory demonstrations and farmer field schools, (4) deliver two short training courses for MoLA officers and student practicums, and (5) evaluate outcomes in terms of adoption, inclusivity, and sustainability.

The project will produce open-access digital extension resources, policy briefs, and capacity building outcomes, providing a tested model for scaling BUAN–MoLA collaboration nationally and regionally.

Contact: Prof. Dixon Olutade Torimiro, Botswana University of Agriculture and Natural Resources, dtorimiro@buan.ac.bw

Abstract

The 2030 Sustainable Development Goals (SDGs) underscore the need for localized, multi-stakeholder partnerships in addressing the interconnected and complex challenges. Two of these very important and underleveraged actors in this agenda in Ethiopia are applied universities and cultural institutions. Applied universities are mandated to engage with the community and offer applied solutions, and cultural institutions foster indigenous knowledge, customs, and heritage that provide locally based know-how for sustainable development. Despite such complementary mandates, the collaboration of the two sectors is weak and institutionally fragmented. Technical solutions are typically tackled by universities in isolation, whereas cultural institutions are afflicted by structural deficits such as underfunding, sectoral disarticulation, and lack of integration with education and policymaking systems. Such nonsystemic cooperation hijacks possible synergies that could produce substantial contributions towards Ethiopia’s SDG achievements.

This research proposed to addresses this gap in a qualitative way to: (1) map the current context of interaction between applied universities, cultural institutions, and policy actors; (2) clarify perceived barriers and enabling factors which shape collaboration; and (3) develop a multi-level strategic framework, grounded in stakeholder perspectives, to guide sustainable partnerships. Data will be collected by means of purposively sampled participants from the three pillars of the Triple Helix: applied universities, cultural institutions, and policy actors. Participants from the universities will included presidents, vice-presidents of research, and faculty members from applied science programs with mandates to engage with the community. Participants from the cultural institutions included directors, curators, and program coordinators across the national-level institutions and regional cultural centers. The policy stakeholders will be recruited from the ministries responsible for the issues of concern, including the Ministry of Education, the Ministry of Culture and Ministry of Tourism. By incorporating information-rich cases, this research hopes to yield actionable findings and create a strategic cooperation model that will enhance the partnership and accelerate the pace of Ethiopia’s sustainable development. This project seeks to foster collaborative research between African and Austrian scholars to contribute SDGs #4 (Quality Education), #11 (Sustainable Cities and Communities), #16 (Peace, Justice, and Strong Institutions), and #17 (Partnerships for the Goals) directly and other SDGs indirectly.

Contact: Tesfaye Fentaw Nigatu (PhD Candidate), Wollo University, Ethiopia, tesfaye.fentaw@wu.edu.et; tesfish064701@gmail.com  

Abstract

Poultry is a major source of protein, yet it is increasingly implicated in the transmission of antibiotic-resistant enterobacteria (ABE), such as Escherichia coli, Klebsiella spp., and Enterobacter spp. These pathogens pose a dual threat of compromising food safety and undermining public health. The indiscriminate use of antibiotics in poultry farming accelerates resistance, with downstream effects on human health and food security directly impacting SDG 2 (Zero Hunger), SDG 3 (Good Health and Well-being), and SDG 17 (Partnerships for the Goals).

This study aims to establish a surveillance framework for detecting and characterizing ABE in poultry farms and retail poultry products. The objectives will include the Identification of resistant enterobacteria in poultry faeces, meat, and farm environments, determining the resistance profiles and genetic markers using molecular techniques. The study will also assess farm-level antibiotic usage practices and correlate with resistance patterns while engaging stakeholders to promote antimicrobial stewardship and policy integration.

Cross-sectional surveillance across commercial poultry farms and retail outlets in south-west Nigeria will be carried out, collecting samples of poultry faeces, meat cuts, water sources, and feed from 30 farms and 20 retail points, while environmental swabs from processing areas will also be collected. Laboratory analysis will include Isolation of enterobacteria, antibiotic susceptibility testing, and PCR and sequencing (WGS or Metagenomic) to detect resistance genes

The expected outcome is to generate baseline data on the prevalence and distribution of resistance while identifying high-risk practices and environments. This will lead to evidence-based recommendations for antibiotic use regulation in poultry and strengthened surveillance capacity and One Health collaboration.

Contact: Abimbola A. Owoseni, Bowen University, Nigeria, abimbola.owoseni@bowen.edu.ng 

Abstract

Antimicrobial resistance poses a significant threat to global health, with foodborne diseases linked to AMR being a widespread problem. The rapid and unpredictable emergence and spread of antibiotic resistance, generally and in the food environment in particular, pose a significant threat to global health, necessitating innovative approaches to understanding and combating this challenge. The application of advanced pattern recognition techniques to identify hidden trends in antibiotic resistance data from ready-to-eat convenience foods will go a long way in mitigating this problem.

This study aims to investigate antibiotic resistance patterns in bacteria isolated from convenience foods in southwestern Nigeria. Leveraging advanced pattern recognition and classification techniques by analysing antibiotic resistance data obtained. Ready-to-eat food samples will be collected from food outlets in each senatorial district from states in the southwestern geopolitical zone in Nigeria. Antibiotic Sensitivity Testing will be done on the isolated bacteria. Metagenomic analyses of the food samples by sampling region will be carried out. Unsupervised learning techniques will be employed to identify hidden patterns in the data. This study is expected to identify key factors driving the emergence and spread of antibiotic resistance in these environments and to develop a robust classification system for antibiotic resistomes. It is also believed that the study will contribute to global knowledge on antibiotic resistance.

Contact: Abimbola A. Owoseni, Bowen University, Nigeria. abimbola.owoseni@bowen.edu.ng 

Abstract

Preeclampsia (PE) remains a major contributor to maternal morbidity, mortality, and future cardiometabolic disease, disproportionately affecting women of African descent. The molecular mechanisms underlying these disparities remain poorly defined. Endothelial dysfunction, a hallmark of PE, represents a key pathway linking pregnancy complications to long-term cardiovascular risk.
This project seeks to identify endothelial molecular signatures associated with PE and to explore how they may differ across populations. Primary human umbilical vein endothelial cells (HUVECs) will be isolated from umbilical cords collected at delivery from women with PE and matched normotensive controls. Local researchers will receive hands-on training in collagenase perfusion, primary culture, and endothelial characterization (morphology, CD31, VE-cadherin). Early-passage HUVECs will undergo 3′ RNA sequencing (outsourced) to capture transcriptomic profiles under normoxic and hypoxic conditions, modeling vascular stress.

Differential expression and pathway enrichment analyses will focus on angiogenesis, nitric oxide signaling, glycocalyx integrity, and inflammatory pathways that may contribute to the cardiometabolic vulnerability observed in women of African descent.

Findings will establish a reproducible in vitro model for endothelial research in pregnancy, generate preliminary transcriptomic data linking endothelial biology to health disparities, and strengthen local capacity for functional genomics and molecular vascular studies.

Contact: Prof. Federica Piani, Medical University of Graz, Austria, Federica.piani@medunigraz.at 

Abstract

Agricultural landscapes in both Ethiopia and Austria face distinct but converging challenges: climate variability, biodiversity loss, soil degradation, and the need to produce healthy food sustainably. Traditional horticultural practices in both regions hold valuable ecological knowledge—ranging from Ethiopia’s resilient moisture-conserving intercropping systems and organic soil amendments, to Austria’s diversified agroecological rotations, community seed systems, and careful landscape stewardship. Meanwhile, advances in precision agriculture offer powerful tools to optimize input use, monitor crop performance, and enhance environmental resilience. This project proposes to co-develop a hybrid regenerative horticultural model that strategically bridges these traditional practices with precision agriculture to build climate-smart food systems suited to both Ethiopian semi-arid and Austrian temperate conditions.

The model will integrate selected traditional techniques from each country, validated through participatory research, and enhanced with low-cost precision tools such as sensor-based irrigation control, data-supported crop planning, and adaptive soil management. Through collaborative field trials, farmer knowledge exchanges, and joint capacity-building programs, the project will refine and adapt the model to local ecological and socio-economic contexts in both regions. Implemented over 24 months, the initiative aims to demonstrate how blending complementary traditions and technologies across climatic zones can boost productivity, strengthen ecological functions, and enhance resilience. This Ethiopia–Austria hybrid approach offers a scalable pathway for transforming horticultural systems into regenerative, climate-smart food systems while fostering cross-continental innovation and knowledge co-creation.

Contact: Seid Hussen Muhie (PhD), Wollo University, Ethiopia, hamidashm@gmail.com 

Abstract

School bullying is a global issue that has negative impacts on victims, perpetrators and bystanders affecting their emotional, social and academic outcomes. Bullying can occur in traditional forms and through technology. This project aims to foster a safe learning environment by leveraging technology to reduce school bullying in Ethiopia. The project will focus on the following key areas:
1.      Increasing awareness of the negative effects of school bullying.
2.      Developing an anonymous reporting system for victims and bystanders.
3.      Establishing a virtual counselling and peer support system for victims of school bullying.
4.      Enhancing parental engagement in monitoring their children's school activities.
5.      Facilitating experience sharing between Austrian and Ethiopian school authorities in preventing bullying through technology.

Contact: Dessalegn Mekuriaw, Debre Markos University, Ethiopia, dessalegnmeku@gmail.com 

Abstract

Debre Markos is a city, separate District, and administrative seat of the East Gojjam Zone in the Amhara National Regional State (ANRS), Ethiopia. A study in 2019, estimated the proportion of the poor people in the city to be 46.8%, with poverty severity index of 37.4%. The introduction of safety net program in Debre Markos city in 2017, which reaffirms this situation, has not yet gone far for many. Debre Markos City Municipality has also been supporting its poorest residents with housing in many parts of the city, but critical challenges remain. Houses for the poor have been constructed in identified locations, facilitating to be stigmatized as “villages of the poor.” In poor houses, the majority of residents are elderly, mothers, and children. Families face hunger, unemployment, lack of education, and social exclusion, with some youth turning to crime, reflecting deep multidimensional poverty requiring a sustainable and empowering intervention.

In 2025, the Debre Markos Women and Social Affairs Department identified 420 vulnerable families, including child-, elderly-, and disability-led households. Considering 5-6 persons per household in the city, the most vulnerable families’ government has constructed houses constitute more than 2100. While provision of housing is a key step forward, these people are usually uneducated, poor, elderly and women without regular incomes, thus, severely experiencing stigma, starvation, and hopelessness. To address their needs, this project proposes a sustainable, community-driven electric mill with grain trading business. The pilot will be launched in two villages of poor houses in a sub-city with a high concentration of poor households. This will be realized only in households where the city government has constructed houses for the poorest of the poor. The project will procure electric mills, some construction materials, and starter grain stock (teff, wheat, and maize) for resale. Training and supervision will ensure smooth operation, while creating jobs for the poor as operators, sellers, cashiers, and security staff for members of the poor households. Community members will form sub-groups to participate in planning, implementation, and management. Land will be allocated by the local government, and labor mobilized to build three mill houses. Owned collectively, the business will distribute profits annually as dividends. Beyond improving household income and self-reliance, the initiative aims to expand and replicate the model across other sub-cities, strengthening community resilience and sustainable development.

Contact: Dessalegn Mekuriaw, Debre Markos University, Ethiopia, dessalegnmeku@gmail.com 

Abstract

Sausage consumption is increasing rapidly in African cities, where sausages paired with chips offer an affordable and convenient meal for millions. Central to sausage production is the casing, which provides structural integrity and enhances product appearance. Despite high demand, most sausage casings in Africa are imported, predominantly from Europe, with local production limited mainly to natural casings derived from animal intestines. Diverse casing types exist—including natural, collagen, cellulose, plastic, and novel co-extruded variants—yet localized manufacture remains underdeveloped, particularly for collagen casings. This proposal addresses the gap in sustainable, locally produced collagen casings by proposing the valorisation of currently underutilized byproducts: bovine, hog, and sheep hides from tanneries and low-value indigenous chicken skins from slaughterhouses. Utilizing these resources could reduce reliance on imports, add value to animal processing byproducts, and stimulate local industry development.

The project will employ a multidisciplinary approach: (i) characterization of raw materials (hides and skins) for collagen suitability; (ii) development and optimization of collagen extraction and casing fabrication protocols; (iii) comparative assessment of mechanical, sensory, and safety properties versus commercial casings; and (iv) evaluation of economic and environmental impacts of local casing production. Eventually the results will be used for validation of protocols for manufacturing high-quality collagen sausage casings from local byproducts, a techno-economic analysis, and recommendations for scalable commercial production. This work aims to advance food innovation, promote circular economy principles, and foster value addition in Africa’s meat processing sector.

Contact: Dr. Benard Oloo, Egerton University, Kenya, olooo.odhiambo@gmail.com, benard.oloo@egerton.ac.ke 

Epilepsy is a neurological multifactorial disorder that affects brain functions. It is characterized by an enduring predisposition to generate seizures, affecting approximately 65 million people, with an additional over 100,000 cases every year. It has been reported that active epilepsy was estimated to affect 9 out of 1,000 people, and lifetime epilepsy at 16 out of 1,000 people in Sub-Saharan Africa. Chrysin (5,7-dihydroxyflavone) is a member of the flavonoid family. Chrysin has been reported to exhibit neuroprotective effects in neurological disorders such as epilepsy, neuronal apoptosis, neuroinflammation, cognitive deficits, and various other age-related neurological conditions. However, there is a paucity of information on the neuroprotective effect of chrysin in epilepsy. Increasing evidence supports the association between mitochondrial oxidative stress, calcium homeostasis, inflammation, and epilepsy. Neuronal compromise during seizure activity depends on intracellular Ca2+ entry and oxidative stress, which may affect neuronal excitability and increase seizure susceptibility. Protecting mitochondria from oxidative stress-mediated injury, maintaining cellular Ca2+ homeostasis, and its associated inflammation and cell death might be an available strategy to salvage neuronal dysfunction in animals or humans with epilepsy. In this set of experiments, I will be studying mitochondrial functions in the pentylenetetrazol (PTZ)-induced epilepsy rat model and the protective effect of chrysin supplementation on calcium homeostasis and receptors, inflammation and apoptosis by investigating the level of mitochondrial H2O2 production, mitochondrial membrane potential and ATP level and assessment of both apoptotic and inflammatory protein markers, redox potential, DNA/RNA oxidative damage, free mitochondrial Ca2+ level, activities of mitochondrial membrane enzymes such Ca2+-Mg2+- ATPases, Ca2+-ATPases and Na+-K+-ATPases, calpains and caspases; IL-1β, IL-6, TNF-α, NFκB, , and other factors such as brain-derived neurotrophic factor (BDNF), cyclic
AMP-responsive element-binding protein (CREB), etc. in the hippocampus, cortex, and cerebellum of the brain of male rats. It is expected from the findings that chrysin might be beneficial in alleviating the behavioral deficits observed in epileptic rats; maintain mitochondrial calcium homeostasis, and prevent cell death and inflammation arising from oxidative stress-mediated injury and calcium overload. It is also expected that chrysin will improve mitochondrial membrane, ATP production level, ATPase enzymes' activities, and modulate neurotransmitters and the expressions of BDNF and CREB.

Contact: Olusegun L. ADEBAYO, Department of Biochemistry, Faculty of Basic Medical Sciences, Redeemer’s University, Ede,
Osun State, Nigeria, adebayool@run.edu.ng.

The global public health crisis posed by Snakebite Envenomation (SBE) is a persistent challenge, classifying it as a critical Neglected Tropical Disease (NTD) that imposes significant mortality and disability, particularly within low-income, rural communities across Sub-Saharan Africa and globally. The current therapeutic standard—polyspecific antivenom derived from hyperimmunized animals—is severely constrained by a host of logistical and clinical barriers, including reliance on a strict cold chain, high manufacturing costs, inconsistent adherence to Good Manufacturing Practice (GMP), limited geographical availability, and variable cross-species efficacy due to venom variation.

This research proposal introduces a focused strategy to circumvent these structural impediments by developing stable, cost-effective Direct Toxin Inhibitors (DTIs). Previous toxicological studies in Namibia have revealed an abundance of Secretory phospholipase A2 (sPLA2) enzymes in the snake venom composition. The sPLA2 enzyme class is responsible for profound myotoxicity and neurotoxicity, making it an ideal, conserved, broad-spectrum target for small-molecule intervention. The strategic necessity dictates that the next generation of snakebite therapy must directly address the logistical challenges of distribution and affordability in remote areas.
The main goal of this research is to collect and document definitive evidence regarding the availability of indigenous plant and marine sources of DTIs in Namibia that contain potent sPLA2 inhibitors. This project moves beyond mere documentation by establishing a rigorous, multi-phase pipeline for extraction, structural elucidation, and comparative efficacy testing. The expectation is that the identification and characterization of lead DTI compounds will provide the molecular template for a highly stable, low-cost therapeutic agent capable of offering reliable, rapid stabilization to SBE victims, thereby fundamentally transforming the clinical management of envenomation across endemic regions. The strategic focus on a stable, small-molecule DTI, potentially derived from locally sourced materials, directly addresses accessibility and cost-effectiveness, linking the project explicitly to sustainable development goals (SDGs) and WHO NTD priorities.

Basic summary
1. Collect seaweeds from Namibia coastline
2. Screen seaweeds for secretory phospholipase A2 (sPLA2).
3. Run both in vitro & in vivo on different snake venom
4. Run structural elucidation of major metabolites

Contact: Prof. Anthony Ishola, University of Namibia, Department of Pharmaceutical Sciences, School of Pharmacy, aishola@unam.na

Cashew Nutshell Liquid (CNSL) residue is a waste obtained after the extraction of CNSL from the cashew nutshell. While CNSL has been transformed into many useful products in developed countries, the residue remains largely as a waste, not only in Africa but globally. Valorization of biomasses is very useful, promising and trending research, particularly in Asia, America and Europe. This research area is gradually developing into future sources of biofuels with a lot of research presently on going. This research proposes the development of sustainable biofuel from CNSL residue. The study aims to valorize the residue obtained after the CNSL has been obtained from the cashew nutshell and compare the biocrude with others from other biomasses.
Hydrothermal Liquefaction (HTL) is a transformative method that is intended to be used for this conversion. It is an efficient method used in the conversion of wet biomass into biocrude. It is expected that the biocrude yield in the CNSL residue will be quite high because it looks like it has high percentage of carbon deposits. The collaborative effort of the Austrian African Partnership is needed for the success of this research that is promising not only to minimize waste but transform waste to wealth, thus achieving double benefits.

Contact: David Gbenga Oke (PhD), Industrial Chemistry Programme, College of Agriculture, Engineering and Science, Bowen University, Nigeria. oke.david@bowen.edu.ng

Background: Keloids are pathological scars that extend beyond the boundaries of the original injury. They are frequently associated with pruritus and pain, exhibit high recurrence rates, and respond poorly to current therapeutic interventions. Keloid formation is disproportionately prevalent in individuals with darker skin (Fitzpatrick phenotype IV-VI), affecting approximately 5–10% of African populations, whereas the incidence in Asian and other populations is markedly lower. Epidemiological studies in the United States have also reported that dark colored patients present with more severe keloids at diagnosis. Despite these observations, the underlying mechanisms driving keloid formation remain poorly understood. Single-cell RNA sequencing (scRNAseq) is a powerful technique that enables the identification of disease-associated cell populations and their transcriptional profiles. Notably, the majority of existing scRNAseq datasets on keloids have been derived from Asian populations, despite the higher prevalence of the condition in individuals of African descent.

Aim: The primary objective of this project is to elucidate the molecular and cellular mechanisms underlying keloid formation and progression in African populations. By analyzing a large cohort of African patients and integrating these data with existing global datasets, we aim to generate a comprehensive understanding of keloid pathophysiology in highly pigmented skin. Given the absence of standardized therapies for keloids, traditional medicine continues to play a significant role in scar management. This project will additionally investigate locally available treatments, such as honey, which has a long history of use in wound healing. Characterizing the bioactive components of such natural remedies may yield cost-effective, accessible, and efficacious therapeutic options for keloid management.

Impact: This initiative will foster collaboration between Austrian dermatological researchers and bioinformatics experts, African surgeons, and traditional medicine practitioners. The project will focus on three key areas: i) Collection and analysis of keloid tissue samples, including advanced single-cell transcriptomic profiling. ii) Development of local expertise in bioinformatics and data analysis. iii) Identification and characterization of active compounds in traditional remedies that promote healthy wound healing.
By integrating contemporary molecular approaches with traditional knowledge, this project aims to advance the understanding of keloid pathogenesis and facilitate the development of novel therapeutic strategies for populations disproportionately affected by this condition.

Contact: Dr. Marcela Bucekova, PhD., Medical University of Vienna, marcela.bucekova@meduniwien.ac.at
 

1. Background and Rationale

Across Africa, aquaculture is rapidly expanding as a key driver of food security, livelihoods, and blue economic growth. However, fish farmers across the continent face persistent challenges related to fish health and environmental stressors, due to parasites, bacterial and fungal infections, deteriorating water quality, chemical pollution, siltation, and climate-induced stressors. These problems are aggravated by limited farmer knowledge and fish health management capacity, weak disease surveillance systems, and insufficient integration between research institutions and extension services.

In Uganda and much of Sub-Saharan Africa, emerging diseases such as Streptococcus agalactiae and Aeromonas hydrophila infections, parasitic infestations (Ichthyophthirius multifiliis, Dactylogyrus spp.), and poor water management practices continue to erode the effort being made to enhance smallholder aquaculture productivity. Moreover, runoff from agricultural chemicals and soil erosion lead to eutrophication and oxygen depletion in ponds and lakes.

To respond sustainably, Busitema University and the National Fisheries Resources Research Institute (NaFIRRI) (Comment by Africa-UniNet Office: NafIRRI is not an active Africa-UniNet member institution and thus not eligible to participate as partner institution in the current call)  propose to develop and pilot a modular, scalable capacity-building system for smallholder fish farmers on fish health management. This system will be technically supported by partnering Austrian universities and institutes under the Africa-UniNet platform, enabling knowledge exchange, co-development of learning modules, and transcontinental application across Africa.

2. Goal and Objectives

Overall Goal

To develop and operationalize a modular, scalable system for strengthening capacity in fish health management, environmental monitoring, and sustainable aquaculture practices across Africa.

Specific Objectives

1. To co-design and pilot modular training packages for fish farmers, extension workers, and trainers on fish health management, biosecurity, and environmental protection.

2. To establish a digital and in-person blended learning system (including open-access e-modules) for scaling up training across Africa.

3. To build institutional partnerships between Busitema University, NaFIRRI, and Austrian universities/institutes under Africa-UniNet for joint technical support, research, and innovation.

4. To create a framework for cross-country adoption and adaptation of the modules by national fisheries institutions in other African countries.

3. The Modular System Approach

The system will consist of interlinked hands-on practical training and knowledge modules, each designed for independent use or integration into a national aquaculture capacity program.

Each draft module will include theory, hands-on practice, demonstration protocols, gender/youth inclusion components, and evaluation tools for measuring uptake and behavioral change among trainees.

4. Expected Outcomes and Innovations

1. A standardized modular fish health management training system co-developed by African and Austrian partners, adaptable across African countries.

2. Enhanced capacity of fish farmers, extension officers, and educators in disease prevention, water quality management, and pollution mitigation.

3. A digital knowledge platform and repository hosting the modules, manuals, and video content for open access.

4. Strengthened collaboration and research networks between Busitema University, NaFIRRI, and Austrian institutions (e.g., University of Natural Resources and Life Sciences – BOKU Vienna, University of Veterinary Medicine Vienna, University of Innsbruck).

5. Pilot implementation sites in Eastern Uganda serving as demonstration hubs for regional replication.

5. Implementation and Partnership Framework

Lead Institutions:

• Busitema University (Faculty of Natural Resources and Fisheries) – Lead academic and training institution.

• National Fisheries Resources Research Institute (NaFIRRI) – Technical lead in fish pathology, diagnostics, and aquaculture systems research. (Comment by Africa-UniNet Office: NafIRRI is not an active Africa-UniNet member institution and thus not eligible to participate as partner institution in the current call) 

Technical Support Partners (Africa-UniNet / Austria): Invited

Contact: Prof. Waiswa Wilson Mwanja, Busitema University,  Director Busitema University Maritime Institute, wwmwanja@yahoo.com

Theileria parva, a tick-borne apicomplexan parasite, is the causative agent of bovine theileriosis leading to over one million cattle deaths annually across sub-Saharan Africa. Transmitted by Rhipicephalus appendiculatus, T. parva imposes severe economic burdens on livestock-dependent communities, with estimated losses exceeding USD 300 million per year. Despite integrated control strategies that including vector management, chemotherapeutics, and the infection and treatment vaccination method, the current vaccination approaches remain outdated, limited in efficacy and scalability. There is a need to develop modern improved vaccines against bovine Theileriosis in order to curb the impact of the disease to agricultural produce and the associated value chain. DNA vaccines subunit vaccines targeting tick antigens have shown partial success in reducing tick viability and parasite transmission, but have not achieved complete transmission blocking. This study aims to decode the molecular interactions at the parasite–vector–host interface, focusing on the salivary gland-mediated transmission of T. parva.

Methods

Omics approaches will be used to characterize the transcriptome and proteome profiles of T. parva sporozoites and adult R. appendiculatus salivary glands during feeding. Additionally, host immune responses upon sporozoite inoculation will be profiled to identify proteins and pathways involved in immune modulation and parasite invasion. Whole-genome sequencing, RNA-sequencing, hybrid capture enrichment, and immunohistochemistry will be employed to map molecular signatures and spatial localization of key transmission factors.

Expected deliverables

By elucidating these interactions, the project seeks to uncover novel targets for transmission-blocking vaccines and diagnostics, thereby advancing livestock disease control in T. parva endemic regions. The findings will contribute to sustainable vaccine development, inform strategies for reducing the impact of bovine theileriosis and provide insights into the control of other Theileria spp.

Contact: Ephraim Chauke (PhD), Scientific and Industrial Research and Development Centre (SIRDC), echauke@sirdc.ac.zw 

The health of humans, animals, and plants as well as the environment are gravely impacted by antimicrobial resistance (AMR) around the world. Antimicrobial use in agriculture, aquaculture, pharmaceutical production, and human use results accumulation of Antimicrobial resistant organisms in environmental compartments including soil, air, water and waste-water which leads spreading of antimicrobial resistant organisms and/or genes across the environment.

AMR in Ethiopia is alarmingly high. Hence, to curb the environmental dimensions of AMR, the One Health approach should be taken into consideration and Ethiopia adopted One Health initiative to combat AMR. However, AMR prevention and containment have not been effectively implemented. In spite of this, robust evidence is needed to inform policy makers and implementers to make evidence-based decisions in the environmental dimension of AMR using a multidisciplinary effort. Therefore, the goal of this project is to implement an environmentally sustainable and integrated One Health strategy that will reduce Ethiopia's current environmental AMR concerns. 

The main objectives of this project are:
1. To establish Environmental Antimicrobial resistance stewardship program on waste management 
2. To reduce antimicrobial use in poultry farming through biosecurity measures
3. To enhance the implementation of antimicrobial stewardship programs in healthcare settings
4. To evaluate the implementation outcomes and identify the enablers and barriers of the implementation outcome

Contact: Agumas Shibabaw Tiruye, Wollo University, Ethiopia, email: agumas.shibabaw@wu.edu.et 

Abstract

In Ethiopia, central and northwestern Ethiopia, in particular (the focus of this proposal), livelihoods are primarily agricultural and much of region is characterized by intensively cultivated mixed farming in which grain production has been dependent on oxen for land preparation.  Different agro climatic zones--wurch (alpine), dega (highland), weyna-dega (medium altitude) and qolla (lowland)--have been important in the development of agriculture, influencing patterns of settlement, mode of production, activities and life of the rural population. 
In northwest Ethiopia, land, as elsewhere in the country, is an indispensable resource. The rest tenure system had been the main tenure system. Rest was a kind of birthright to the land and in principle it was inherited from generation to generation. People who descended from the founding father could own the land on both individual and community based. Collectively, they were owners of the land. The system was naturally developed from communal life. 
The 1975 land proclamation made land to be the property of the state and the people. This agrarian reform eliminated many of the basic problems inherited from the pre-revolutionary agricultural system in the country. It reorganized different agricultural forms of production. The vast majority of households and farms became individual run peasant farms. The derg land reform and redistribution was a continuous process. The reform was followed by the sowing of seeds for only subsistence grain production and consequently the land reform that was successful in eradicating the feudal order, failed to fulfill the objective of peasant prosperity and ensuring abundant supply of food for the fast-growing population of the country-both in rural and urban areas. This continuous division and re-division of land has caused not only land fragmentation but also scattered agricultural land in Ethiopia today.  The Derg agrarian reform also continued in Post-1991 Ethiopia. Peasants expressed their grievances against the agrarian reforms in different ways. Though they revolted against both the Derg and EPRDF, they failed to transform the rural unrest into a popular revolt.

Data for this study will be gathered using both primary and secondary sources. Primary data, which will constitute the principal source of information for the study, will be elicited using multiple data collection methods. The study will employ methodological approach that will provide an in-depth understanding of complex historical and present contexts in which the research questions and objectives are situated. Both qualitative and quantitative data will be generated, and this requires carrying out a combination of data analysis methods. The qualitative data will be summarized using qualitative data processing tools. Both diverging and converging issues on particular issues will be identified and used for analysis, in the context of the research objectives.
 

Contact: Prof. Temesgen Gebeyehu Baye, Professor of History, Department of History, Bahir Dar University, Bahir Dar, Ethiopia, Email: temebaye5@gmail.com

Abstract
Polyhydroxyalkanoates (PHAs) are biodegradable polymers synthesized through microbial fermentation, providing a sustainable alternative to conventional plastics amidst rising concerns about plastic waste. This proposal presents a project focused on the optimization and pilot-scale production of PHAs using locally available and inexpensive substrates. Building on prior work that successfully isolated and screened bacterial strains for PHA production from Addis Ababa municipal solid waste, this project will screen various local substrates, including agricultural residues and food waste, to identify the most effective options for PHA production. The study involves a systematic screening process to evaluate substrate suitability and conduct preliminary fermentation tests. Following this, response surface methodology (RSM) will be employed to optimize production conditions, focusing on key parameters such as temperature, pH levels, and nutrient ratios to maximize PHA yield. Subsequently, pilot-scale production will be implemented in a bioreactor. Expected outcomes include identifying effective low- or no-cost substrates that enhance PHA production, optimizing production conditions to increase yields, and demonstrating the feasibility of pilot-scale production using locally available substrates. This project aims not only to advance PHA production methods but also to contribute to waste management solutions and promote environmental sustainability. By utilizing local resources and reducing reliance on conventional plastics, this initiative seeks to foster economic viability in bioplastics production while addressing the critical issue of plastic waste. 

Contact: Dr. Zuriash Mamo, zuriash.mamo@aastu.edu.et (Addis Ababa Science and Technology University)

Abstract
Poverty alleviation and reduced inequalities are two of the core goals in the United Nations Sustainable Development Goals (SDGs). Microfinance institutions (MFIs), a type of financial institutions that provide financial services to the poor people who are denied credit access from commercial banks, are vital to attain these and other global initiatives by sustaining the provision of financial services (specifically, microcredits) for the impoverished. Despite the crucial role of MFIs in poverty eradication, reduced inequalities and other SDGs, there is surprisingly no evidence on the role of environmental sustainability in MFI social performance and sustainability. Climate change is one of the grand global challenges with adverse effects on the societies, ecosystems and physical environment threatening at least 85 percent of the population globally (ICRW, 2023). The poor are often more vulnerable to climate risk as they, for instance, disproportionately work in agriculture livelihood, which is highly climate-exposed sector (Zetterli, 2023). Financial services (specifically, microcredits) to the disadvantaged groups (eg. the poor) are among the main adaptation strategies to increase resilience to climate change. Nevertheless, adverse climate changes could also affect the feasibility of economic investments and the resource allocation decision of MFIs and reduce financial inclusion and, therefore, jeopardize the attainment of SDGs. For example, based on data from the banking sector in Pakistan, Umar et al. (2025) reveals that climate change leads to financial vulnerabilities, a deterioration of portfolio quality and a rise in default risk. Hence, the performance of the microfinance industry and MFI sustainability could also be sensitive to the changes in a nation’s climate vulnerability.

Accordingly, our study will address two important empirical questions: Does climate change affect MFIs’ lending behavior adversely? Or Is there a need for MFIs to revisit their microcredit model for a climate change responsive lending behavior to increase climate adaptation for the vulnerable poor? Does institutional quality support a climate resilient lending behavior? Furthermore, the sustainability (survival) of MFIs is also crucial for sustainable poverty alleviation and reduced inequalities as MFIs cannot continue to support the poor if they fail to exist as a going concern. Hence, our study will also investigate the effect of climate change on MFI sustainability (solvency or inversely, risk of bankruptcy). As one of the possible pathways to mitigate any adverse effect of climate change, we also explore the role of institutional quality in increasing climate resilience of the microfinance industry. That is, does a stronger institutional quality mitigate any adverse effect of climate change on MFI solvency?

In order to address the above objectives, we will use panel data of MFIs from Sub-Saharan Africa with a time span of 15 years to be obtained from the World Bank Microfinance Information Exchange (MIX) Market data catalog. Data on climate change and institutional quality will be accessed from the World Bank World Development Indicators (WDI) and World Governance Indicators (WGI) database, respectively. We will analyze the data by applying dynamic data analysis techniques namely the Generalized Methods of Moments (GMM), which is  an advanced method preferred to static panel data modeling techniques such as the Ordinary Least Square (OLS), random effects Generalized Least Square (GLS) and fixed effects regression analysis methods to deal with endogeneity, heteroskedasticity and autocorrelation problems. To ensure the validity of our findings, various sensitivity and robustness checks will also be made including differential effects of climate change on lending behavior and MFI sustainability across different scale of MFI operations, profit status, regulation status and locations, among other things.

The research output will be published in the form of journal articles and could contribute to the body of knowledge and evidence-informed policymaking by uncovering the role of environmental sustainability in expanding credit access for the poor and in reducing the risk of MFI bankruptcy in the context of developing countries, especially, sub-Saharan Africa. This research could also provide valuable insights as to the role of institutional quality for a climate resilient lending behavior and microfinance industry. We promise that we will exploit our potential fully, publish high quality research papers and contribute our best to the academic and research world as well as Bahir Dar University and partnering University in Austria, upholding value for money. The scope of the study can be modified in discussion with the coordinator from the partnering University in Austria after getting your consent and the partnering opportunities. We are very grateful for any assistance you extend to us and look forward to your prompt response regarding the partnering opportunities. Thank you

Contact: Tilahun Aemiro Tehulu (PhD), Associate Professor of Finance Department of Accounting and Finance, College of Business and Economics, Bahir Dar University, Ethiopia
E-mail: tilahuntehulug@gmail.com, ORCID: https://orcid.org/0000-0002-7421-8091

Large Language Models, a type of generative AI, can play a transformative role in agriculture by providing personalized recommendations and insights. These aren't just generic suggestions; the AI can tailor its advice to the specific needs of different stakeholders—from individual farmers and agronomists to government officials and NGOs. Imagine a system that can understand the unique challenges of a small family farm in one of the countryside and an industrial-scale operation in another, offering advice that is relevant and actionable for each. This personalized approach is key to improving efficiency and sustainability across the entire agricultural sector. The real power of this technology lies in combining the capabilities of the LLM with real-time data. This project seeks to harness that synergy by integrating information from various sources. Sensors buried in the soil can report on moisture and nutrient levels, cameras can monitor crop health, and environmental monitors can track temperature and humidity. By feeding this live data into the LLM, the system can provide dynamic, up-to-the-minute guidance. For example, a farmer could receive an alert about a potential pest infestation based on camera images, along with a recommended course of action from the AI, all in real time. This integration of data and advanced language processing is designed to empower everyone involved in the agricultural value chain, enabling them to make more informed decisions and build a more resilient food system. 

It is because agriculture serves as the backbone of the Ethiopian economy, providing the primary source of livelihood and employment for the majority of its population. However, this vital sector faces significant challenges that hinder its potential. Farmers often contend with inconsistent yields, a result of poor soil management practices and the unpredictable effects of climate change. Furthermore, the limited access to real-time data on everything from weather patterns to market prices leaves many stakeholders in the dark, making it difficult to make informed decisions. These hurdles directly impact food security and the overall productivity of the nation's farms. By introducing modern technology and embracing data-driven decisionmaking, there is an opportunity to revolutionize the sector, boosting efficiency and creating a more resilient agricultural future for Ethiopia.

Contact: Dr. Gebeyehu Belay Gebremeskel, Associate Professor, Bahir Dar University, Bahir Dar Institute of Technology: Computing Faculty. Email: Gebeyehu gebeyehu2009@gmail.com
 

Abstract

Chronic wounds and bacterial skin infections remain major public-health burdens, particularly in low-resource settings such as Ethiopia, where limited access to effective wound-care therapies and rising antimicrobial resistance prolong morbidity. Concurrently, the global demand for safe, plant-derived agents with proven wound-healing and antibacterial properties is increasing. Ethiopia’s traditional medicinal knowledge includes numerous plant species used for treating wounds and skin infections; however, these remedies remain largely unvalidated and underexplored at the phytochemical and pharmacological levels. This collaborative project between Ethiopian and Austrian research institutions seeks to scientifically validate and characterize bioactive compounds from Ethiopian medicinal plants traditionally used for wound treatment and skin infections. The study will integrate ethnobotanical knowledge, phytochemical analysis, and biological evaluation using a multidisciplinary research framework. Selected medicinal plants will be collected based on ethnobotanical surveys and prepared as methanolic and aqueous extracts. These extracts will undergo comprehensive in vitro screening, including: Antibacterial assays (Minimum Inhibitory Concentrations-MIC) against clinically relevant wound pathogens such as Staphylococcus aureus, Streptococcus pyogenes, Pseudomonas aeruginosa, and Escherichia coli; Antioxidant (DPPH, ABTS) and anti-inflammatory (COX inhibition) assays to evaluate their wound-repair and skin-protective potential; and In vitro wound-healing assays, such as fibroblast migration (scratch test) and collagen synthesis studies, to assess tissue regeneration activity. The most active extracts will be subjected to bioassay-guided fractionation to isolate and identify major bioactive compounds using advanced chromatographic and spectroscopic techniques (LC-MS, NMR). By combining Ethiopia’s biodiversity and ethnomedicinal heritage with Austria’s analytical and bioassay expertise, this project will generate scientific evidence, capacity building, and novel lead compounds for future therapeutic development. 
 

Contact: Getachew A Ewonetu, MD, MSc, PhD Fellow in translational Medicine, Debre Tabor University, Debre Tabor, Ethiopia
Email: getachew.abebe_e@aau.edu.et, gechfirst@gmail.com, Whatsapp No: +251953984278
 

Abstract

This proposal seeks funding for a 24-month project to conduct a comprehensive analysis of climate change impacts over East Africa from 2000-2024 using a multi-sensor satellite data archive. East Africa is a climate change hot-spot, experiencing increased frequency of extreme weather events, including droughts and floods, with severe consequences for food security, water resources, and economic stability. Despite this, there remains a critical gap in accessible, high-resolution, and actionable climate information for local decision-makers.
Our project will leverage data from key satellite missions (e.g., MODIS, Landsat, GRACE, TRMM/GPM) to quantify decadal trends in key climate indicators: land surface temperature, rainfall patterns, vegetation health, soil moisture, and water body dynamics. By integrating this geospatial data with socio-economic datasets, we will produce vulnerable area maps and an interactive, open-access East Africa Climate Resilience Dashboard. The project's direct outcomes include enhanced forecasting capacity for regional meteorological agencies, evidence-based policy briefs for governments, and tailored information for farmers and water managers. This project will empower East African nations to build resilience and adapt proactively to the escalating climate crisis.

Key-Words: Climate Change, East Africa, Satellite Data, Remote Sensing, Earth Observation, Climate Resilience, Climate Adaptation, Environmental Monitoring

Contact: Ambachew Abeje Alemu (PhD), Assistant Professor, Atmospheric Physics, Email: bdu1207638@bdu.edu.et, ambaabe@dtu.edu.et, ambnehabe21@gmail.com
 

Abstract 
Ethiopia faces a significant food security challenge, with post-harvest losses (PHL) of cereals and legumes exceeding 35–40% due to pest infestation, fungal spoilage, and inadequate storage systems. Climate variability has intensified these losses by increasing aflatoxin contamination and reducing grain quality. While hermetic storage and improved handling technologies have been introduced, scalability and affordability remain major barriers to widespread adoption among smallholder farmers. This project, 'Innovating Post-Harvest Loss Reduction Technologies for Climate- Resilient Grain Systems in Ethiopia,' aims to design, validate, and localize climate-smart post-harvest technologies that integrate bio-based pest deterrents, enhanced hermetic storage systems, and low-cost digital sensors for real-time monitoring. Building on previous collaborative work under the Feed the Future Post-Harvest Loss Reduction Lab (Kansas State University) and NMBU-supported mycotoxin mitigation programs, the project introduces an applied innovation pathway combining biotechnology, engineering, and data-driven design. The partnership will merge Austrian expertise in engineering, bioprocessing, and sensor technology with Ethiopian capacity in field validation, microbial bio-protection, and technology dissemination. Over a 30-month implementation period, the consortium will deliver two validated prototypes capable of reducing grain losses by over 40%, supported by institutional capacity-building, SME engagement, and farmer training. The project aligns with Africa-UniNet’s priorities in Food Security, Climate Resilience, and Applied Research Collaboration, contributing directly to SDGs. 

Contact: Dr. Samuel Alemayehu Lapiso, Assistant Professor of Biology, Mekelle University, Email: samuel.alemayhu@mu.edu.et

Abstract
Indoor air pollution remains an overlooked public health threat, with heating, ventilation, and air conditioning (HVAC) and air conditioner (AC) systems serving as reservoirs for pathogenic and mycotoxin-producing fungi. Exposure to airborne mycotoxins such as aflatoxins, fumonisins, and ochratoxins are linked to immune suppression, neurological disorders, and liver damage. This study aims to investigate the presence of fungi and concentration of mycotoxins in AC / HVAC filters (Nigerian and Austrian) and to develop clove-derived nanoparticles material as a cheaper and an eco-friendly treatment option for the common fungi and mycotoxins found. Dust samples from the filters will be collected and analyzed for fungi using molecular method and mycotoxins will be evaluated using liquid chromatography–mass spectrometry (LC-MS). Clove-Derived Nanoparticles will be synthesized and tested for their efficiency in degrading common mycotoxins, afterwards the efficient materials will be characterized (SEM, XRD, FTIR, BET, and TEM). Their efficiency will also be tested for fungi/mycotoxin treatment in food and water sources. The expected outcome includes baseline data on airborne mycotoxin contamination in indoor environments (Nigerian and Austrian) and the development of effective, plant-based nanoparticle treatment with potential application relevant to HVAC systems, food, and water purification. This project aligns with SDG 3 (Good Health and Well-Being) and offers a sustainable approach to improving indoor air quality and public health safety.

Contact: Moyosoreoluwa Abegunde, Redeemer's University, Nigeria, Email: abegunde14007@run.edu.ng

Abstract

East Africa’s dairy sector stands on the cusp of transformation through artificial intelligence (AI). This project proposes to harness responsible AI – AI that is inclusive, ethical, and locally driven – to boost productivity and improve livelihoods in the region’s dairy value chain. We will investigate how AI tools can enhance farm efficiency (in areas like animal health monitoring, nutrition, and supply chain management) while ensuring that benefits reach smallholder farmers, including women, youth, and persons with disabilities who form the backbone of the largely informal dairy industry. The research will generate much-needed evidence on AI’s socio-economic impacts: we will assess current policies and data gaps, pilot innovative AI applications on farms, and measure outcomes such as increased milk yields, higher incomes, and reduced labor burdens for marginalized groups. By actively engaging local stakeholders and prioritizing data sovereignty, the project aims to foster local innovation instead of one-size-fits-all imported solutions. Anticipated outputs include an AI-enhanced dairy management prototype, policy briefs with recommendations for government and industry, and an open-access repository of project data to inform future research. Ultimately, this initiative will demonstrate how equitable AI can drive economic transformation in East African agriculture – creating new opportunities and better jobs, especially for women and young people – while safeguarding against digital exclusion.

Contact:  Fredu Nega Tegebu, Mekelle University, Ethiopia, fredu.nega@mu.edu.et

Abstract
The semi-arid highlands of Tigray, northern Ethiopia, are among the most environmentally fragile areas in Sub-Saharan Africa. Severe land degradation, declining soil fertility, and loss of vegetation cover have left vast landscapes treeless and unproductive. Local communities, whose livelihoods depend largely on rainfed agriculture, face recurrent crop failures and food insecurity. Agroforestry presents a sustainable pathway to restore degraded land and improve resilience against climate stress. Faidherbia albida, an indigenous leguminous tree species, has exceptional ecological and agronomic benefits, it improves soil nitrogen, enhances microclimate conditions, and supports higher crop yields under its canopy. However, its establishment in degraded, dryland areas is constrained by low seed germination, slow growth, and poor seedling survival under harsh conditions. The use of arbuscular mycorrhizal fungi (AMF) can greatly enhance root development, nutrient uptake, and drought tolerance in seedlings. Combining AMF inoculation with both seed-based and vegetative propagation offers a promising solution for successful F. albida establishment and large-scale agroforestry expansion. This project aims to establish sustainable Faidherbia-based agroforestry systems in treeless areas of Tigray by integrating local ecological knowledge with modern mycorrhizal biotechnology and participatory farmer engagement.

Contact: Solomon Amare, MSc in Botany, PhD  in Soil Science, Mekelle University, Ethiopia, Email: solomon.amare@mu.edu.et

Abstract

Smallholder farmers, mainly in that of the developing countries such as Africa, are playing a crucial role in food production and nutritional security. However, they are often facing significant challenges in accessing modern agricultural technologies, including smallholder mechanization. Capacity pinch points are blocking the scaling of mechanization equipment and practices particularly for market-based scaling for instance. Hence, With Africa’s population expected to double by 2050, the continent must ditch traditional smallholder farming in favor of modern technology such as examining capacity needs and defining capacity strengthening approaches in the context of smallholder mechanization ecosystem. This project proposal is therefore developed to comply with a general objective to contribute to effective human resource capacity needs of smallholder farming systems and proposes targeted capacity strengthening approaches to enhance smallholder mechanization ecosystem in Ethiopia.

A mixed-methods approach will be employed in order to realize this objective. The data organization will follow qualitative and quantitative approaches to satisfy reliability, replication, and validity of the project. The qualitative approach will help to gain insight of the existing baseline of smallholder mechanization capacity needs and capacity strengthening approaches and the quantitative approach will be used to construct explanations and empirical findings obtained from the qualitative approach.

Finally, a comprehensive assessment report; A curriculum and training manuals; Capacity of critical agricultural mechanization actors and their value chain; Productivity and profitability, household income, and food and nutritional security; Smallholder mechanization research centers and knowledge institutions; Collaboration and linkage at national and regional levels; Policy recommendations and implementation roadmap; Workshop and seminars; preparation and submission of scientific paper; A final report will be the intermediate and final outputs of this research project.

Contact: Tsegay Tesfay Mezgebe, PhD, M.Sc., B.Sc., Mekelle University, Ethiopia, Email: tsegay.tesfay@mu.edu.et 

Abstract

Food insecurity and malnutrition remain pressing global challenges, particularly in Ethiopia, where over half the population is food insecure and child undernutrition is prevalent. Diarrheal diseases further exacerbate this crisis by impairing nutrient absorption and increasing child mortality. Traditional Ethiopian fermented foods, notably Metata Ayib, a spiced, long-shelf-life fermented cottage cheese, offer untapped potential as functional foods with nutritional and therapeutic value. This project aims to craft Metata Ayib as a nutrient-dense, safe, and functional food to support child and maternal nutrition and manage diarrhea.

The study involves capacity building in hygienic milk handling, isolation and characterization of probiotic and fermentative microbes from Metata Ayib and related fermented foods, and screening for probiotic potential using both in vitro and in vivo models. Whole-genome sequencing will identify probiotic gene signatures for candidate selection. The best-performing strains will be used to optimize lab-scale fermentation of Metata Ayib, followed by physicochemical, nutritional, sensory, and antimicrobial evaluations. Animal model studies will assess the product’s effects on growth, gut microbiota modulation, immunity, and healing responses. Ultimately, pilot-scale production and promotion will support commercialization and integration into local food systems.

This project seeks to transform an indigenous Ethiopian dairy product into a scientifically validated, safe, and functional food, addressing nutritional deficiencies and contributing to Sustainable Development Goal 2 Zero Hunger.

Contact: Dr, Dagnew Bitew, Institue of Biotechnology, Bahir Dar University, Email: dagnew.bitew@bdu.edu.et 

Abstract

The goal of this project is to reduce post-harvest losses among smallholder women farmers in Sub-Saharan Africa by designing, developing, and testing solar-powered grain dryers with integrated temperature and humidity control. By installing at least three working prototypes in a few rural communities over the course of 18 months, it specifically aims to reduce grain spoilage during the drying phase by 40–60%. The dryers will be designed to be inexpensive, simple to operate, and climate-adaptable. The project makes sure the technology is in line with the real-world requirements and limitations of women-led farming systems by using participatory design and field validation. The initiative supports food security, income stability, and gender-responsive agricultural innovation by improving grain quality, storage life, and market value.

Contact: Goitom Tesfay Gebreselassie(PhD), Mekelle University, Department of Manufacturing Engineering, Tigray, Ethiopia, goitom.tesfay2@mu.edu.et

Abstract

Traditional fermented foods and beverages are an important source of nutrition and cultural identity in Ethiopia. However, uncontrolled fermentation processes may lead to the formation of ethyl carbamate, a potentially carcinogenic compound that poses a significant food safety risk. This project aims to develop and evaluate innovative, safe fermentation approaches to minimize ethyl carbamate formation in sorghum- and millet-based nutritional beverages such as bread, injera and shamita. The study will integrate traditional knowledge with modern analytical and microbiological techniques to identify key fermentation parameters microbial strain selection, temperature, pH, and fermentation duration that influence toxin formation. Analytical quantification will be performed using HPLC-based methods to validate process improvements. The project will generate evidence-based guidelines for safer household and small-scale cereal fermentations, contributing to improved food safety, nutrition, and community health. Collaboration with an Austrian partner will strengthen capacity building, technology transfer, and sustainable food innovation within Ethiopia’s local food systems. The expected outcomes directly support the UN Sustainable Development Goals (SDGs), particularly SDG 2 (Zero Hunger), SDG 3 (Good Health and Well-Being), SDG 9 (Industry, Innovation and Infrastructure), and SDG 12 (Responsible Consumption and Production).

Contact: Tesfamichael Gebretsadkan, Mekelle University, School of Pharmacy, tesfamichael.gebretsadkan@mu.edu.et

Abstract

Phosphorus, a macronutrient that is limiting in the soil, is known as a major component in all biological macromolecules. Phosphorus is a needful element for the early division of the totipotent cells of plant root meristematic bundles. It facilitates plant growth and development, from the molecular level to many biochemical and physiological activities like photosynthesis, flowering, seed production, etc.  This study focused on the isolation and molecular identification of Phosphate Solubilizing Microorganisms, (PSMs), obtained from rhizospheric soil and composted fruit waste samples. Presumptive microbiological cultural methods, biochemical assays, 16S rRNA, and ITS File genomes, were used for the isolation and molecular identification of the PSMs. The organisms identified and characterized, were assigned accession numbers on the National Centre for Biotechnology Information (NCBI) database. Variants of Biophosphate fertilizers produced with these PSMs were utilized as soil additives to cultivate eight varieties of common crops: maize, soybean, habanero, and cassava on spent farm plots allocated at the International Institute for Tropical Agriculture (IITA), Ibadan. 

The research seeks collaborations from Austrian researchers who may harness data acquisitions, cost-effective innovations, and climate-change resilient crop production opportunities it offers. This is a scale up phase of the research, improving on the previous test crops, where crops like tomatoes, fruits, and other purposively selected vegetables will be included as staple food crops, to be cultivated, using this proven, cost-effective, and eco-friendly technology, in order to achieve optimally sustainable agricultural productivity, without jeopardizing soil and environmental health. The is also an initiative, taking actions in achieving SDGs 2, 8, 9, 12, and 15, in Nigeria, Austria and other regions of the world that are willing to collaborate and improve on these goals.

Key words: Phosphorus, Macronutrient, Tropical Agriculture, SDGs, NCBI.

Contact: Dr. Esther O. Tella, Lead City University, Department of Biological Science, Faculty of Natural and Applied Sciences, Ibadan, Nigeria; bukolatella23@gmail.com, tella.esther@lcu.edu.ng

Abstract

It is well recognized that the economic development of a nation can be achieved only when its available resources are effectively utilized. Developing countries, in particular, are expected to harness their natural resources to ensure rapid and inclusive economic growth. In this context, Ethiopia is known to be one of the richest countries in terms of sisal cultivation. However, this valuable resource remains largely underutilized from a scientific and industrial perspective. Traditionally, sisal fibers in Ethiopia have been used for producing ropes, hats, bags, and similar products. Yet, this natural fiber holds great potential as an input for various engineering applications, especially in the textile and composite industries, which serve as a sustainable alternative to conventional materials. Moreover, sisal is a biodegradable material, making it environmentally friendly. Its attractive mechanical and physical properties further position it as a promising resource for the development of eco-friendly composite materials. The current underutilization of sisal in Ethiopia should be addressed, transforming it into one of the country’s key economic development sectors. To achieve this, the nation’s overall potential in sisal production must be comprehensively explored, and an efficient value chain should be designed and implemented to ensure sustainable utilization. In addition, mechanisms should be established to use waste generated after fiber extraction for biogas energy production. This integrated approach would not only promote sustainability but also enhance the economic benefits for farmers engaged in sisal cultivation, ultimately improving their livelihoods.

Contact: Dr. Eshetie Kassegn, Department of Manufacturing Engineering, Mekelle University, Mekelle, Ethiopia, eshetie.kassegn@mu.edu.et 

Abstract

Lake Chivero, the primary water source for Harare, Zimbabwe, faces multifaceted contamination challenges from long-term nutrient loading, heavy metals, pathogenic microbes, and emerging organic pollutants originating from untreated sewage, industrial effluents, agricultural runoff, and urban stormwater. These contaminants have led to severe eutrophication, persistent cyanobacterial harmful algal blooms, the proliferation of invasive aquatic weeds, and frequent fish kills, significantly degrading the lake’s ecological integrity and compromising public health. Recent studies document elevated levels of heavy metals such as lead and mercury, antibiotic-resistant bacteria, and microplastic pollution, further exacerbating ecosystem stress and water treatment complexities. Biodiversity assessments reveal loss of land animals, native fish species and disruptions in aquatic food webs, alongside shifts favouring tolerant invasive species and cyanobacteria dominance. This research proposes a novel integrated eco-engineering and bioremediation framework that synergises nature-based wastewater polishing wetlands, sediment nutrient and pollutant recovery technologies, phytoremediation targeting microbial and chemical contaminants, and participatory community-driven catchment restoration to holistically remediate Lake Chivero. Grounded in Integrated Water Resource Management (IWRM) and the World Lake Vision governance principles, the study will quantify nutrient and contaminant fluxes, model attenuation of emerging and legacy pollutants across restoration interventions, and evaluate ecological recovery and socio-economic benefits. Expected outcomes include substantial reductions in nitrogen, phosphorus, heavy metals, and microbial pathogens; restoration of dissolved oxygen and native aquatic biodiversity; and enhanced resilience of Harare’s urban water supply. This replicable framework aims to inform sustainable lake restoration across data-scarce, resource-constrained African urban water systems facing complex contamination pressures. Collaboration with Africa-UniNet will foster vital technical exchange, capacity building, and applied research on hydrological and ecological linkages among water resources, forest ecosystems, and agricultural landscapes, enhancing the integrated eco-engineering and bioremediation framework for Lake Chivero by leveraging multidisciplinary expertise and promoting sustainable catchment restoration approaches that align with regional development and environmental governance goals.

Contact: Dr Farai Matawa, Director; Environmental Science Institute (ESI), Scientific and Industrial Research and Development Centre (SIRDC), fmatawa@sirdc.ac.zw 

Abstract

Artisanal and small-scale gold mining (ASGM) in Zimbabwe is a vital economic activity that provides livelihoods for over a million people, contributing significantly to the country's foreign currency earnings. However, the widespread use of mercury in gold extraction within this sector poses grave environmental and public health threats. Mercury, a potent neurotoxin, contaminates water, soil, sediment, vegetation, and aquatic fauna, with risks amplified by its transformation into methylmercury that bioaccumulates and biomagnifies in food chains. This contamination jeopardises both ecosystems and human populations, particularly vulnerable groups such as children and pregnant women. Despite Zimbabwe’s commitment to the Minamata Convention on Mercury, enforcement challenges and informal mining practices hinder effective mercury management. This study investigates the spatial distribution and ecological impacts of mercury pollution in the Mazowe Catchment, a biodiversity-rich and agriculturally vital watershed heavily impacted by ASGM activities. Through extensive seasonal field sampling and monitoring of multiple environmental media, it quantifies mercury concentrations, identifies pollution hotspots, and evaluates bioaccumulation in fish and terrestrial vegetation. The project also explores integrated remediation strategies that involve engineered substrate amendments (biochar, lime, bentonite) and phytoremediation using locally adapted hyperaccumulator plant species, such as Vetiveria zizanioides. These approaches aim to immobilise mercury, reduce its bioavailability, and restore ecosystem health. By combining environmental chemistry, ecological risk assessment, and community stakeholder engagement, the project aims to generate robust empirical data that inform science-based policies and remediation protocols. The outcomes will support Zimbabwe’s compliance with international environmental obligations, facilitate sustainable restoration of mercury-contaminated landscapes, and contribute to reducing human health risks associated with mercury exposure. This multidisciplinary approach is essential for balancing economic development with environmental sustainability in Zimbabwe’s ASGM sector.

Contact: Dr Farai Matawa, Director; Environmental Science Institute (ESI), Scientific and Industrial Research and Development Centre (SIRDC), fmatawa@sirdc.ac.zw 

Abstract

Background: Ethiopia is one of the countries severely impacted by climate change-related extreme events (floods, droughts). The extreme events threaten the health system through increased water-borne and vector borne diseases, and malnutrition (Simane et al., 2016, OCHAEthiopia, 2024, Yeshambel et al., 2024). High vulnerability and low adaptive capacity worsen the situation in the country (Richardson et al., 2022). The government efforts to address the problem often excludes local knowledge and community perspectives. The National Adaptation Plan lacks mechanism for co-creating climate information, leading to ineffective risk communication and maladaptation. This proposal aims to develop a climate information co-production service to bridge the gap, leveraging robust community health infrastructure and local knowledge to build resilient health system in the country. The proposal has three main objectives: co-create a framework by integrating the local climate knowledge with scientific data for health planning; develop locally-tailored, accessible early warning and risks communication tools; and enable science-policy linkages through evidence-based dialogues.

Methodology: This project is proposed operate in Dire Dawa administration and East Hararghe Zone (Oromia region), both located in eastern Ethiopia. Dire Dawa represents flood-prone areas, facing water-borne and emerging diseases (Cholera/Diarrhea, dengue). East Hararghe, droughtaffected area with malnutrition problem. The project will be executed in four phases: 1) Assessment and engagement phase: this includes selection of stakeholders and identify flood/drought-vulnerable Woredas (districts), prioritizing associated diseases (diarrhea/Cholera and malnutrition). There will be participatory vulnerable assessment with communities, health extension (HEWs), and local leaders, while documenting local indicators of climate-related health risks; 2) Knowledge integration and co-design phase: Joint workshops integrating local knowledge, climate projections (from Meteorology) and health data (from Ministry of Health) to co-design context-specific interventions: community-based surveillance networks using local observations, climate-informed communication materials in local languages (Amharic and Oromiffa), and adapted HEWs training module; 3) Pilot and Refine phase: Co-designed interventions (participatory disease hot spot mapping, climate-health radio programs, and local early warning committees). The effectiveness will be monitored through community and health worker feedback loops; 4) Policy Engagement phase: Regional and national policy dialogues presenting evidence and co-produced tools, advocating for climate resilience integration into district health plans and national policies. This creates strategic opportunities to embed co-production in Ethiopia’s HNAP, Ethiopia’s Public Health Emergency Management (PHEM) system (MOH and EPHI, 2022).

Expected outcomes and impacts: This project will deliver a validated co-production framework for integrated local knowledge into Ethiopia’s climate-health planning. It will develop culturally appropriate tools to boost community awareness and early action, empower HEWs, communities, and local health officials to identify and respond to climate-related health risks, and generate evidence-based recommendations for policies. Ultimately, it will reduce climate-sensitive diseases that the MOH identified through proactive, community-owned interventions. The project will transform the country’s health system from the reactive to proactive, fostering resilience by centering local knowledge and co-production (Jacob et al., 2025). It creates sustainable collaborative pathways for communities, health workers, and policymakers to address the climaterelated health crisis, serving as model for other regions in the country. By bridging the science, policy, and local knowledge, it ensures the health systems are robust, equitable, and responsive to those most at risk. More importantly, the collaborative work between Haramaya University and institutions from Austria will strengthen the tie to tackle the global challenges, and enhance the local knowledge and skills in the field. 

Contact: Abraham Geremew (PhD), Haramaya University, abraham.geremew@haramaya.edu.et 

Abstract

Ageing has been associated with the onset of a host of protein misfolding diseases/neurodegenerative diseases, two of these diseases being Alzheimer’s (AD) diseases and Parkinson disease (Hou et al., 2019; Koszła & Sołek, 2024).  The exact cause of AD is not fully well known but its histopathology is characterized by the development of senile plaques which are essentially depositions/aggregates of beta-amyloid peptide (Aβ) and neurofibrillary tangles (NFT’s) composed of Tau microtubule protein. In Alzheimer’s disease the Amyloid precursor protein (APP) is cleaved through two known pathways. Pathway one involving alpha and gamma secretase and pathway two involving Beta and gamma secretase (Chen et al., 2017; Zhang et al., 2023; Zhang et al., 2011). The second pathway is chiefly responsible for the formation of undesirable beta-amyloid peptide (Aβ) proteins which aggregate and then go on to cause Alzheimer’s. Three major methods have been proposed as strategies to tackle protein misfolding related diseases. The three strategies include: decreasing the production of the troublesome proteins, preventing the protein from aggregating and removing the aggregates from the brain. The model organism C. elegans has been proposed as a potential tool that can be used to evaluate these strategies of how best to treat AD. C. elegans as a model organism is advantageous in that it is small, transparent, has a short life span, non-parasitic and roughly 38% of the genes have a human ortholog such as APP and Tau. Natural products which contain a wide range of compounds have been proposed as potential therapeutic sources for AD. The use of C. elegans to assess the efficacy of these natural products is highly feasible. The natural products can be administered through different methods, either they can be ingested as food, or absorbed through the cuticle or through the worms neuronal sensory cilia. 

Research Questions:
Can bio-active compounds from existing natural herbs have a therapeutic effect on AD?
Can C. elegans be used as a model organism to identify bio-active compounds with a therapeutic effect on AD?
Can non-recombinant proteins be produced and assays developed for in vitro studies using herbs and their identified bio-active compounds?
Can the efficacy of bio-active compounds be improved by coating nanoparticles with bioactive compounds? 

Aim:
To investigate if and if so to what extent do locally available herbs inhibit or activate the activity of the following list of enzymes: Alpha secretase, Beta secretase, Gamma Secretase, Ubiquitin, E1,E2, E3, Monoamine Oxidase, (MAO) and catechol-o-methyl transferase (COMT) 
To investigate if the herbs enhance life span, health span in the transgenic worm models for AD.
To check for the formation of protein aggregates in the transgenic strains exposed to the herbs.

Relevance:
The work will help to further establish C. elegans as a model organism for studying protein related misfolding diseases and neurodegenerative diseases. The findings will also help identify  herbs that carry active compounds that have a therapeutic effect on AD. The research will also help to deduce if coating of nanopaticles with bioactive compounds improves their efficacy.

Contact: Dr Vimbai Samukange, Scientific and Industrial Research and Development Centre, Zimbabwe, vsamukange@sirdc.ac.zw 
 

Abstract

Uganda’s vision 2040 emphasises sustainable natural resource management, recognising forests, water, and the environment as essential pillars for economic growth and socio-economic transformation besides forest protection providing natural resilience to climate change effects. One key result aimed at reducing the area of degraded forests and landscapes from 20,000 ha in FY 2023/24 to 50,000 ha in FY 2029/30. In order to address forest cover loss, this new project builds on recently old but now digitized and published forest data including some biodiversity survey baseline data that is now available. The two-year project will bring different stakeholders to dialogue on the management options of the forest. Stakeholders will provide data that will be synthesized for information that can be used to develop a management framework for this central forest reserve. This will also provide information to aid and boost the tourism potential in the region. Promoting biodiversity conservation and sustainable management is a strategic intervention and so a community communication strategy will be developed.

The research questions include an assessment of the area under liberation compared to the area under reforestation.

Secondly, gender forest conservation challenges in the region will be studied and communicated to different stakeholders for developing specific strategic responses.
Last but not least an assessment of the impact and effectiveness of community livelihood interventions around the degraded forest will be done as increasing forest cover should bring socio-economic and ecological benefits and generally climate smart development particularly. 

Contact: Sara Kaweesa (PhD, BOKU). Conservation Agriculture expert at A Rocha Uganda and Nkumba University, Entebbe Uganda; shkaweesa@gmail.com, ckaggwa@nkumbauniversity.ac.ug