Exploring the Prevalence and Structural Analysis of Outer Membrane Proteins in Brucella Detected in Humans, Cattle, Cattle Products and Environment

Cooperating countries: Nigeria and Austria

Coordinating institution: Redeemer's University, Onikepe Folarin, folarino@run.edu.ng

Partner institution: Medical University of Vienna

Project duration: 1 September 2024 - 31 August 2026

Abstract: 

Brucellosis is one of the neglected tropical diseases which is gradually becoming global health burden affecting many communities in most developing countries. The disease is caused by Brucella, a bacterium which usually infects animals such as cattle, goats, pigs and dogs resulting into great economic loss to farmers. The disease is also transfected via infected animals to humans through direct contact, consumption of affected animals’ product or by inhalation of contaminated air resulting into fever and other complications.  This study sought to assess the prevalence of brucellosis among cattle, cattle milk, cattle slaughter, beef consumers and the environment (water and soil) around the slaughter areas in Nigeria. In addition, factors associated with transmission and pathogenesis of this disease will be elucidated. Questionnaire will be used to collect data on socio-demographic characteristics and human brucellosis related risk factors while appropriate laboratory and molecular techniques will be used to isolate and characterize the causative organism (Brucella spp.). Furthermore, the antimicrobial susceptibility testing will be carried out for recommendation of effective therapies and the molecular structure of the outer membrane proteins of the organism will be elucidated for probable roles in efficient and rapid detection of the organism. This study will encourage multidisciplinary research into pathogenesis and detection of brucellosis.  The outcome of this study is important in achieving sustainable development goals (SDGs) specifically numbers 1, 3, and 12:  No Poverty, Good Health and Well-being, and Responsible consumption and production respectively.