Novel mechanic biomarkers influencing clotting in type 2 diabetes mellitus patients

Cooperating countries: South Africa and Austria

Coordinating institution: Medical University of Vienna, Ursula Windberger ursula.windberger@meduniwien.ac.at 

Partner institutions: University of Pretoria

Project duration: 

Budget: EUR 30.120

Abstract: 

This study combines research and teaching. 

Research: type 2 diabetes mellitus (T2DM) is characterized by dysregulated glucose homeostasis. Uncontrolled T2DM is associated with increased inflammation, oxidative stress, and coagulopathies, contributing to diabetes-associated complications. This study develops new biomarkers for the mechanical performance of clots in controlled and uncontrolled patient cohorts and connects them to the morphology of blood/clot components. Clot performance during mechanical stretch (clot plasticity at increments of shear stresses) via rheometric LAOStress protocols, and blood microrheology are included to tests of red blood cell, platelet, and fibrin fiber morphology, fiber architecture of the clot, and protein C concentration. Experimental data will be connected with clinical data to describe the diverse patient populations living in South Africa and abroad (Black, White, and Indian populations of both sexes are included). 

Teaching: with the rheometer that is provided by the manufacturer for this project, we start training courses for students and workshops for scientists. This will foster the internalization of the participating universities and lively student exchange.